Gamma-aminobutyric acid type B receptor subunit 2 (GABA-B receptor 2) (GABA-B-R2) (GABA-BR2) (GABABR2) (Gb2) (G-protein coupled receptor 51) (HG20)
1_MASPR 6_ SSGQP 11_ GPPPP 16_ PPPPP 21_ ARLLL 26_ LLLLP 31_ LLLPL 36_ APGAW 41_ GWARG 46_ APRPP 51_ PSSPP 56_ LSIMG 61_ LMPLT 66_ KEVAK 71_ GSIGR 76_ GVLPA 81_ VELAI 86_ EQIRN 91_ ESLLR 96_ PYFLD 101_ LRLYD 106_ TECDN 111_ AKGLK 116_ AFYDA 121_ IKYGP 126_ NHLMV 131_ FGGVC 136_ PSVTS 141_ IIAES 146_ LQGWN 151_ LVQLS 156_ FAATT 161_ PVLAD 166_ KKKYP 171_ YFFRT 176_ VPSDN 181_ AVNPA 186_ ILKLL 191_ KHYQW 196_ KRVGT 201_ LTQDV 206_ QRFSE 211_ VRNDL 216_ TGVLY 221_ GEDIE 226_ ISDTE 231_ SFSND 236_ PCTSV 241_ KKLKG 246_ NDVRI 251_ ILGQF 256_ DQNMA 261_ AKVFC 266_ CAYEE 271_ NMYGS 276_ KYQWI 281_ IPGWY 286_ EPSWW 291_ EQVHT 296_ EANSS 301_ RCLRK 306_ NLLAA 311_ MEGYI 316_ GVDFE 321_ PLSSK 326_ QIKTI 331_ SGKTP 336_ QQYER 341_ EYNNK 346_ RSGVG 351_ PSKFH 356_ GYAYD 361_ GIWVI 366_ AKTLQ 371_ RAMET 376_ LHASS 381_ RHQRI 386_ QDFNY 391_ TDHTL 396_ GRIIL 401_ NAMNE 406_ TNFFG 411_ VTGQV 416_ VFRNG 421_ ERMGT 426_ IKFTQ 431_ FQDSR 436_ EVKVG 441_ EYNAV 446_ ADTLE 451_ IINDT 456_ IRFQG 461_ SEPPK 466_ DKTII 471_ LEQLR 476_ KISLP 481_ LYSIL 486_ SALTI 491_ LGMIM 496_ ASAFL 501_ FFNIK 506_ NRNQK 511_ LIKMS 516_ SPYMN 521_ NLIIL 526_ GGMLS 531_ YASIF 536_ LFGLD 541_ GSFVS 546_ EKTFE 551_ TLCTV 556_ RTWIL 561_ TVGYT 566_ TAFGA 571_ MFAKT 576_ WRVHA 581_ IFKNV 586_ KMKKK 591_ IIKDQ 596_ KLLVI 601_ VGGML 606_ LIDLC 611_ ILICW 616_ QAVDP 621_ LRRTV 626_ EKYSM 631_ EPDPA 636_ GRDIS 641_ IRPLL 646_ EHCEN 651_ THMTI 656_ WLGIV 661_ YAYKG 666_ LLMLF 671_ GCFLA 676_ WETRN 681_ VSIPA 686_ LNDSK 691_ YIGMS 696_ VYNVG 701_ IMCII 706_ GAAVS 711_ FLTRD 716_ QPNVQ 721_ FCIVA 726_ LVIIF 731_ CSTIT 736_ LCLVF 741_ VPKLI 746_ TLRTN 751_ PDAAT 756_ QNRRF 761_ QFTQN 766_ QKKED 771_ SKTST 776_ SVTSV 781_ NQAST 786_ SRLEG 791_ LQSEN 796_ HRLRM 801_ KITEL 806_ DKDLE 811_ EVTMQ 816_ LQDTP 821_ EKTTY 826_ IKQNH 831_ YQELN 836_ DILNL 841_ GNFTE 846_ STDGG 851_ KAILK 856_ NHLDQ 861_ NPQLQ 866_ WNTTE 871_ PSRTC 876_ KDPIE 881_ DINSP 886_ EHIQR 891_ RLSLQ 896_ LPILH 901_ HAYLP 906_ SIGGV 911_ DASCV 916_ SPCVS 921_ PTASP 926_ RHRHV 931_ PPSFR 936_VMVSG
1: Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed:15617512, PubMed:18165688, PubMed:22660477, PubMed:24305054, PubMed:9872316, PubMed:9872744). Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (PubMed:18165688). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed:10075644, PubMed:10773016, PubMed:24305054). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (PubMed:10075644, PubMed:10773016, PubMed:10906333, PubMed:9872744). Plays a critical role in the fine-tuning of inhibitory synaptic transmission (PubMed:22660477, PubMed:9872744). Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (PubMed:10075644, PubMed:22660477, PubMed:9872316, PubMed:9872744). Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (Probable)