Diacylglycerol O-acyltransferase 1 (EC 2.3.1.20) (ACAT-related gene product 1) (Acyl-CoA retinol O-fatty-acyltransferase) (ARAT) (Retinol O-fatty-acyltransferase) (EC 2.3.1.76) (Diglyceride acyltransferase)
1_MGDRG 6_ SSRRR 11_ RTGSR 16_ PSSHG 21_ GGGPA 26_ AAEEE 31_ VRDAA 36_ AGPDV 41_ GAAGD 46_ APAPA 51_ PNKDG 56_ DAGVG 61_ SGHWE 66_ LRCHR 71_ LQDSL 76_ FSSDS 81_ GFSNY 86_ RGILN 91_ WCVVM 96_ LILSN 101_ ARLFL 106_ ENLIK 111_ YGILV 116_ DPIQV 121_ VSLFL 126_ KDPYS 131_ WPAPC 136_ LVIAA 141_ NVFAV 146_ AAFQV 151_ EKRLA 156_ VGALT 161_ EQAGL 166_ LLHVA 171_ NLATI 176_ LCFPA 181_ AVVLL 186_ VESIT 191_ PVGSL 196_ LALMA 201_ HTILF 206_ LKLFS 211_ YRDVN 216_ SWCRR 221_ ARAKA 226_ ASAGK 231_ KASSA 236_ AAPHT 241_ VSYPD 246_ NLTYR 251_ DLYYF 256_ LFAPT 261_ LCYEL 266_ NFPRS 271_ PRIRK 276_ RFLLR 281_ RILEM 286_ LFFTQ 291_ LQVGL 296_ IQQWM 301_ VPTIQ 306_ NSMKP 311_ FKDMD 316_ YSRII 321_ ERLLK 326_ LAVPN 331_ HLIWL 336_ IFFYW 341_ LFHSC 346_ LNAVA 351_ ELMQF 356_ GDREF 361_ YRDWW 366_ NSESV 371_ TYFWQ 376_ NWNIP 381_ VHKWC 386_ IRHFY 391_ KPMLR 396_ RGSSK 401_ WMART 406_ GVFLA 411_ SAFFH 416_ EYLVS 421_ VPLRM 426_ FRLWA 431_ FTGMM 436_ AQIPL 441_ AWFVG 446_ RFFQG 451_ NYGNA 456_ AVWLS 461_ LIIGQ 466_ PIAVL 471_ MYVHD 476_ YYVLN 481_YEAPA
1: Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates (PubMed:16214399, PubMed:18768481, PubMed:28420705, PubMed:32433610, PubMed:32433611, PubMed:9756920). Highly expressed in epithelial cells of the small intestine and its activity is essential for the absorption of dietary fats (PubMed:18768481). In liver, plays a role in esterifying exogenous fatty acids to glycerol, and is required to synthesize fat for storage (PubMed:16214399). Also present in female mammary glands, where it produces fat in the milk (By similarity). May be involved in VLDL (very low density lipoprotein) assembly (PubMed:18768481). In contrast to DGAT2 it is not essential for survival (By similarity). Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders (PubMed:16214399). Exhibits additional acyltransferase activities, includin acyl CoA:monoacylglycerol acyltransferase (MGAT), wax monoester and wax diester synthases (By similarity). Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (PubMed:28420705)