Sterol O-acyltransferase 2 (EC 2.3.1.26) (Acyl-coenzyme A:cholesterol acyltransferase 2) (ACAT-2) (Cholesterol acyltransferase 2)
1_MEPGG 6_ ARLRL 11_ QRTEG 16_ LGGER 21_ ERQPC 26_ GDGNT 31_ ETHRA 36_ PDLVQ 41_ WTRHM 46_ EAVKA 51_ QLLEQ 56_ AQGQL 61_ RELLD 66_ RAMRE 71_ AIQSY 76_ PSQDK 81_ PLPPP 86_ PPGSL 91_ SRTQE 96_ PSLGK 101_ QKVFI 106_ IRKSL 111_ LDELM 116_ EVQHF 121_ RTIYH 126_ MFIAG 131_ LCVFI 136_ ISTLA 141_ IDFID 146_ EGRLL 151_ LEFDL 156_ LIFSF 161_ GQLPL 166_ ALVTW 171_ VPMFL 176_ STLLA 181_ PYQAL 186_ RLWAR 191_ GTWTQ 196_ ATGLG 201_ CALLA 206_ AHAVV 211_ LCALP 216_ VHVAV 221_ EHQLP 226_ PASRC 231_ VLVFE 236_ QVRFL 241_ MKSYS 246_ FLREA 251_ VPGTL 256_ RARRG 261_ EGIQA 266_ PSFSS 271_ YLYFL 276_ FCPTL 281_ IYRET 286_ YPRTP 291_ YVRWN 296_ YVAKN 301_ FAQAL 306_ GCVLY 311_ ACFIL 316_ GRLCV 321_ PVFAN 326_ MSREP 331_ FSTRA 336_ LVLSI 341_ LHATL 346_ PGIFM 351_ LLLIF 356_ FAFLH 361_ CWLNA 366_ FAEML 371_ RFGDR 376_ MFYRD 381_ WWNST 386_ SFSNY 391_ YRTWN 396_ VVVHD 401_ WLYSY 406_ VYQDG 411_ LRLLG 416_ ARARG 421_ VAMLG 426_ VFLVS 431_ AVAHE 436_ YIFCF 441_ VLGFF 446_ YPVML 451_ ILFLV 456_ IGGML 461_ NFMMH 466_ DQRTG 471_ PAWNV 476_ LMWTM 481_ LFLGQ 486_ GIQVS 491_ LYCQE 496_ WYARR 501_ HCPLP 506_ QATFW 511_ GLVTP 516_RSWSC
1: Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol (PubMed:11294643, PubMed:16647063). Plays a role in lipoprotein assembly and dietary cholesterol absorption (PubMed:11294643). Utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) and linolenoyl-CoA ((9Z,12Z,15Z)-octadecatrienoyl-CoA) as substrates (PubMed:11294643). May provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa (PubMed:11294643)
2: Has lower enzymatic activity compared to isoform 1
3: Has lower enzymatic activity compared to isoform 1