Diacylglycerol kinase iota (DAG kinase iota) (DGK-iota) (EC 2.7.1.107)
1_MDAAG 6_ RGCHL 11_ LPLPA 16_ ARGPA 21_ RAPAA 26_ AAAAA 31_ ASPPG 36_ PCSGA 41_ ACAPS 46_ AAAGA 51_ GAMNP 56_ SSSAG 61_ EEKGA 66_ TGGSS 71_ SSGSG 76_ AGSCC 81_ LGAEG 86_ GADPR 91_ GAGSA 96_ AAAGA 101_ AALDE 106_ PAAAG 111_ QKEKD 116_ EALEE 121_ KLRNL 126_ TFRKQ 131_ VSYRK 136_ AISRA 141_ GLQHL 146_ APAHP 151_ LSLPV 156_ ANGPA 161_ KEPRA 166_ TLDWS 171_ ENAVN 176_ GEHLW 181_ LETNV 186_ SGDLC 191_ YLGEE 196_ NCQVR 201_ FAKSA 206_ LRRKC 211_ AVCKI 216_ VVHTA 221_ CIEQL 226_ EKINF 231_ RCKPT 236_ FREGG 241_ SRSPR 246_ ENFVR 251_ HHWVH 256_ RRRQE 261_ GKCKQ 266_ CGKGF 271_ QQKFS 276_ FHSKE 281_ IVAIS 286_ CSWCK 291_ QAFHN 296_ KVTCF 301_ MLHHI 306_ EEPCS 311_ LGAHA 316_ AVIVP 321_ PTWII 326_ KVKKP 331_ QNSLK 336_ ASNRK 341_ KKRTS 346_ FKRKA 351_ SKRGM 356_ EQENK 361_ GRPFV 366_ IKPIS 371_ SPLMK 376_ PLLVF 381_ VNPKS 386_ GGNQG 391_ TKVLQ 396_ MFMWY 401_ LNPRQ 406_ VFDLS 411_ QEGPK 416_ DALEL 421_ YRKVP 426_ NLRIL 431_ ACGGD 436_ GTVGW 441_ ILSIL 446_ DELQL 451_ SPQPP 456_ VGVLP 461_ LGTGN 466_ DLART 471_ LNWGG 476_ GYTDE 481_ PVSKI 486_ LCQVE 491_ DGTVV 496_ QLDRW 501_ NLHVE 506_ RNPDL 511_ PPEEL 516_ EDGVC 521_ KLPLN 526_ VFNNY 531_ FSLGF 536_ DAHVT 541_ LEFHE 546_ SREAN 551_ PEKFN 556_ SRFRN 561_ KMFYA 566_ GAAFS 571_ DFLQR 576_ SSRDL 581_ SKHVK 586_ VVCDG 591_ TDLTP 596_ KIQEL 601_ KFQCI 606_ VFLNI 611_ PRYCA 616_ GTMPW 621_ GNPGD 626_ HHDFE 631_ PQRHD 636_ DGYIE 641_ VIGFT 646_ MASLA 651_ ALQVG 656_ GHGER 661_ LHQCR 666_ EVMLL 671_ TYKSI 676_ PMQVD 681_ GEPCR 686_ LAPAM 691_ IRISL 696_ RNQAN 701_ MVQKS 706_ KRRTS 711_ MPLLN 716_ DPQSV 721_ PDRLR 726_ IRVNK 731_ ISLQD 736_ YEGFH 741_ YDKEK 746_ LREAS 751_ ISDWL 756_ RTIAG 761_ ELVQS 766_ FGAIP 771_ LGILV 776_ VRGDC 781_ DLETC 786_ RMYID 791_ RLQED 796_ LQSVS 801_ SGSQR 806_ VHYQD 811_ HETSF 816_ PRALS 821_ AQRLS 826_ PRWCF 831_ LDDRS 836_ QEHLH 841_ FVMEI 846_ SQDEI 851_ FILDP 856_ DMVVS 861_ QPAGT 866_ PPGMP 871_ DLVVE 876_ QASGI 881_ SDWWN 886_ PALRK 891_ RMLSD 896_ SGLGM 901_ IAPYY 906_ EDSDL 911_ KDLSH 916_ SRVLQ 921_ SPVSS 926_ EDHAI 931_ LQAVI 936_ AGDLM 941_ KLIES 946_ YKNGG 951_ SLLIQ 956_ GPDHC 961_ SLLHY 966_ AAKTG 971_ NGEIV 976_ KYILD 981_ HGPSE 986_ LLDMA 991_ DSETG 996_ ETALH 1001_ KAACQ 1006_ RNRAV 1011_ CQLLV 1016_ DAGAS 1021_ LRKTD 1026_ SKGKT 1031_ PQERA 1036_ QQAGD 1041_ PDLAA 1046_ YLESR 1051_ QNYKV 1056_IGHED
1: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:23949095, PubMed:9830018). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Has probably no preference for any of the diacylglycerols in terms of the acyl chain composition, especially for the acyl chain at the sn-2 position (PubMed:9830018). By controlling the diacylglycerol/DAG-mediated activation of RASGRP3, negatively regulates the Rap1 signaling pathway. May play a role in presynaptic diacylglycerol/DAG signaling and control neurotransmitter release during metabotropic glutamate receptor-dependent long-term depression (By similarity)