Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (Beta-PAK) (Oligophrenin-3) (p21-activated kinase 3) (PAK-3)
1_MSDGL 6_ DNEEK 11_ PPAPP 16_ LRMNS 21_ NNRDS 26_ SALNH 31_ SSKPL 36_ PMAPE 41_ EKNKK 46_ ARLRS 51_ IFPGG 56_ GDKTN 61_ KKKEK 66_ ERPEI 71_ SLPSD 76_ FEHTI 81_ HVGFD 86_ AVTGE 91_ FTPDL 96_ YGSQM 101_ CPGKL 106_ PEGIP 111_ EQWAR 116_ LLQTS 121_ NITKL 126_ EQKKN 131_ PQAVL 136_ DVLKF 141_ YDSKE 146_ TVNNQ 151_ KYMSF 156_ TSGDK 161_ SAHGY 166_ IAAHP 171_ SSTKT 176_ ASEPP 181_ LAPPV 186_ SEEED 191_ EEEEE 196_ EEDEN 201_ EPPPV 206_ IAPRP 211_ EHTKS 216_ IYTRS 221_ VVESI 226_ ASPAV 231_ PNKEV 236_ TPPSA 241_ ENANS 246_ STLYR 251_ NTDRQ 256_ RKKSK 261_ MTDEE 266_ ILEKL 271_ RSIVS 276_ VGDPK 281_ KKYTR 286_ FEKIG 291_ QGASG 296_ TVYTA 301_ LDIAT 306_ GQEVA 311_ IKQMN 316_ LQQQP 321_ KKELI 326_ INEIL 331_ VMREN 336_ KNPNI 341_ VNYLD 346_ SYLVG 351_ DELWV 356_ VMEYL 361_ AGGSL 366_ TDVVT 371_ ETCMD 376_ EGQIA 381_ AVCRE 386_ CLQAL 391_ DFLHS 396_ NQVIH 401_ RDIKS 406_ DNILL 411_ GMDGS 416_ VKLTD 421_ FGFCA 426_ QITPE 431_ QSKRS 436_ TMVGT 441_ PYWMA 446_ PEVVT 451_ RKAYG 456_ PKVDI 461_ WSLGI 466_ MAIEM 471_ VEGEP 476_ PYLNE 481_ NPLRA 486_ LYLIA 491_ TNGTP 496_ ELQNP 501_ ERLSA 506_ VFRDF 511_ LNRCL 516_ EMDVD 521_ RRGSA 526_ KELLQ 531_ HPFLK 536_ LAKPL 541_ SSLTP 546_ LIIAA 551_KEAIK
1: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as a downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development. In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (By similarity)