E3 SUMO-protein ligase PIAS2 (EC 2.3.2.-) (Androgen receptor-interacting protein 3) (ARIP3) (DAB2-interacting protein) (DIP) (E3 SUMO-protein transferase PIAS2) (Msx-interacting zinc finger protein) (Miz1) (PIAS-NY protein) (Protein inhibitor of activated STAT x) (Protein inhibitor of activated STAT2)
1_MADFE 6_ ELRNM 11_ VSSFR 16_ VSELQ 21_ VLLGF 26_ AGRNK 31_ SGRKH 36_ DLLMR 41_ ALHLL 46_ KSGCS 51_ PAVQI 56_ KIREL 61_ YRRRY 66_ PRTLE 71_ GLSDL 76_ STIKS 81_ SVFSL 86_ DGGSS 91_ PVEPD 96_ LAVAG 101_ IHSLP 106_ STSVT 111_ PHSPS 116_ SPVGS 121_ VLLQD 126_ TKPTF 131_ EMQQP 136_ SPPIP 141_ PVHPD 146_ VQLKN 151_ LPFYD 156_ VLDVL 161_ IKPTS 166_ LVQSS 171_ IQRFQ 176_ EKFFI 181_ FALTP 186_ QQVRE 191_ ICISR 196_ DFLPG 201_ GRRDY 206_ TVQVQ 211_ LRLCL 216_ AETSC 221_ PQEDN 226_ YPNSL 231_ CIKVN 236_ GKLFP 241_ LPGYA 246_ PPPKN 251_ GIEQK 256_ RPGRP 261_ LNITS 266_ LVRLS 271_ SAVPN 276_ QISIS 281_ WASEI 286_ GKNYS 291_ MSVYL 296_ VRQLT 301_ SAMLL 306_ QRLKM 311_ KGIRN 316_ PDHSR 321_ ALIKE 326_ KLTAD 331_ PDSEI 336_ ATTSL 341_ RVSLM 346_ CPLGK 351_ MRLTI 356_ PCRAV 361_ TCTHL 366_ QCFDA 371_ ALYLQ 376_ MNEKK 381_ PTWIC 386_ PVCDK 391_ KAAYE 396_ SLILD 401_ GLFME 406_ ILNDC 411_ SDVDE 416_ IKFQE 421_ DGSWC 426_ PMRPK 431_ KEAMK 436_ VSSQP 441_ CTKIE 446_ SSSVL 451_ SKPCS 456_ VTVAS 461_ EASKK 466_ KVDVI 471_ DLTIE 476_ SSSDE 481_ EEDPP 486_ AKRKC 491_ IFMSE 496_ TQSSP 501_ TKGVL 506_ MYQPS 511_ SVRVP 516_ SVTSV 521_ DPAAI 526_ PPSLT 531_ DYSVP 536_ FHHTP 541_ ISSMS 546_ SDLPG 551_ LDFLS 556_ LIPVD 561_ PQYCP 566_ PMFLD 571_ SLTSP 576_ LTASS 581_ TSVTT 586_ TSSHE 591_ SSTHV 596_ SSSSS 601_ RSETG 606_ VITSS 611_ GSNIP 616_DIISL
1: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. Isoform PIAS2-beta, but not isoform PIAS2-alpha, promotes MDM2 sumoylation. Isoform PIAS2-alpha promotes PARK7 sumoylation. Isoform PIAS2-beta promotes NCOA2 sumoylation more efficiently than isoform PIAS2-alpha. Isoform PIAS2-alpha sumoylates PML at'Lys-65' and 'Lys-160'