Pre-mRNA-splicing factor SPF27 (Breast carcinoma-amplified sequence 2) (DNA amplified in mammary carcinoma 1 protein) (Spliceosome-associated protein SPF 27)
1_MAGTG 6_ LVAGE 11_ VVVDA 16_ LPYFD 21_ QGYEA 26_ PGVRE 31_ AAAAL 36_ VEEET 41_ RRYRP 46_ TKNYL 51_ SYLTA 56_ PDYSA 61_ FETDI 66_ MRNEF 71_ ERLAA 76_ RQPIE 81_ LLSMK 86_ RYELP 91_ APSSG 96_ QKNDI 101_ TAWQE 106_ CVNNS 111_ MAQLE 116_ HQAVR 121_ IENLE 126_ LMSQH 131_ GCNAW 136_ KVYNE 141_ NLVHM 146_ IEHAQ 151_ KELQK 156_ LRKHI 161_ QDLNW 166_ QRKNM 171_ QLTAG 176_ SKLRE 181_ MESNW 186_ VSLVS 191_ KNYEI 196_ ERTIV 201_ QLENE 206_ IYQIK 211_ QQHGE 216_ANKEN
1: Required for pre-mRNA splicing as component of the activated spliceosome (PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:29360106, PubMed:30705154). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR)