Cell cycle checkpoint protein RAD17 (hRad17) (RF-C/activator 1 homolog)
1_MSKTF 6_ LRPKV 11_ SSTKV 16_ TDWVD 21_ PSFDD 26_ FLECS 31_ GVSTI 36_ TATSL 41_ GVNNS 46_ SHRRK 51_ NGPST 56_ LESSR 61_ FPARK 66_ RGNLS 71_ SLEQI 76_ YGLEN 81_ SKEYL 86_ SENEP 91_ WVDKY 96_ KPETQ 101_ HELAV 106_ HKKKI 111_ EEVET 116_ WLKAQ 121_ VLERQ 126_ PKQGG 131_ SILLI 136_ TGPPG 141_ CGKTT 146_ TLKIL 151_ SKEHG 156_ IQVQE 161_ WINPV 166_ LPDFQ 171_ KDDFK 176_ GMFNT 181_ ESSFH 186_ MFPYQ 191_ SQIAV 196_ FKEFL 201_ LRATK 206_ YNKLQ 211_ MLGDD 216_ LRTDK 221_ KIILV 226_ EDLPN 231_ QFYRD 236_ SHTLH 241_ EVLRK 246_ YVRIG 251_ RCPLI 256_ FIISD 261_ SLSGD 266_ NNQRL 271_ LFPKE 276_ IQEEC 281_ SISNI 286_ SFNPV 291_ APTIM 296_ MKFLN 301_ RIVTI 306_ EANKN 311_ GGKIT 316_ VPDKT 321_ SLELL 326_ CQGCS 331_ GDIRS 336_ AINSL 341_ QFSSS 346_ KGENN 351_ LRPRK 356_ KGMSL 361_ KSDAV 366_ LSKSK 371_ RRKKP 376_ DRVFE 381_ NQEVQ 386_ AIGGK 391_ DVSLF 396_ LFRAL 401_ GKILY 406_ CKRAS 411_ LTELD 416_ SPRLP 421_ SHLSE 426_ YERDT 431_ LLVEP 436_ EEVVE 441_ MSHMP 446_ GDLFN 451_ LYLHQ 456_ NYIDF 461_ FMEID 466_ DIVRA 471_ SEFLS 476_ FADIL 481_ SGDWN 486_ TRSLL 491_ REYST 496_ SIATR 501_ GVMHS 506_ NKARG 511_ YAHCQ 516_ GGGSS 521_ FRPLH 526_ KPQWF 531_ LINKK 536_ YRENC 541_ LAAKA 546_ LFPDF 551_ CLPAL 556_ CLQTQ 561_ LLPYL 566_ ALLTI 571_ PMRNQ 576_ AQISF 581_ IQDIG 586_ RLPLK 591_ RHFGR 596_ LKMEA 601_ LTDRE 606_ HGMID 611_ PDSGD 616_ EAQLN 621_ GGHSA 626_ EESLG 631_ EPTQA 636_ TVPET 641_ WSLPL 646_ SQNSA 651_ SELPA 656_ SQPQP 661_ FSAQG 666_ DMEEN 671_ IIIED 676_YESDG
1: Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage (PubMed:10208430, PubMed:11418864, PubMed:11687627, PubMed:11799063, PubMed:12672690, PubMed:14624239, PubMed:15235112). Has a weak ATPase activity required for binding to chromatin (PubMed:10208430, PubMed:11418864, PubMed:11687627, PubMed:11799063, PubMed:12672690, PubMed:14624239, PubMed:15235112). Participates in the recruitment of the 9-1-1 (RAD1-RAD9-HUS1) complex and RHNO1 onto chromatin, and in CHEK1 activation (PubMed:21659603). Involved in homologous recombination by mediating recruitment of the MRN complex to DNA damage sites (PubMed:24534091). May also serve as a sensor of DNA replication progression (PubMed:12578958, PubMed:14500819, PubMed:15538388)