Cyclin-dependent kinase 2-associated protein 2 (CDK2-associated protein 2) (DOC-1-related protein) (DOC-1R)
1_MSYKP 6_ IAPAP 11_ SSTPG 16_ SSTPG 21_ PGTPV 26_ PTGSV 31_ PSPSG 36_ SVPGA 41_ GAPFR 46_ PLFND 51_ FGPPS 56_ MGYVQ 61_ AMKPP 66_ GAQGS 71_ QSTYT 76_ DLLSV 81_ IEEMG 86_ KEIRP 91_ TYAGS 96_ KSAME 101_ RLKRG 106_ IIHAR 111_ ALVRE 116_ CLAET 121_ERNAR
1: Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:33283408). Inhibits cell cycle G1/S phase transition by repressing CDK2 expression and activation; represses CDK2 activation by inhibiting its interaction with cyclin E and A (PubMed:23781148). Plays a role in regulating the self-renewal of embryonic stem cells (ESCs) and in maintaining cell survival during terminal differentiation of ESCs (By similarity). Regulates microtubule organization of metaphase II oocytes (By similarity)