Triple functional domain protein (EC 2.7.11.1) (PTPRF-interacting protein)
1_MSGSS 6_ GGAAA 11_ PAASS 16_ GPAAA 21_ ASAAG 26_ SGCGG 31_ GAGEG 36_ AEEAA 41_ KDLAD 46_ IAAFF 51_ RSGFR 56_ KNDEM 61_ KAMDV 66_ LPILK 71_ EKVAY 76_ LSGGR 81_ DKRGG 86_ PILTF 91_ PARSN 96_ HDRIR 101_ QEDLR 106_ RLISY 111_ LACIP 116_ SEEVC 121_ KRGFT 126_ VIVDM 131_ RGSKW 136_ DSIKP 141_ LLKIL 146_ QESFP 151_ CCIHV 156_ ALIIK 161_ PDNFW 166_ QKQRT 171_ NFGSS 176_ KFEFE 181_ TNMVS 186_ LEGLT 191_ KVVDP 196_ SQLTP 201_ EFDGC 206_ LEYNH 211_ EEWIE 216_ IRVAF 221_ EDYIS 226_ NATHM 231_ LSRLE 236_ ELQDI 241_ LAKKE 246_ LPQDL 251_ EGARN 256_ MIEEH 261_ SQLKK 266_ KVIKA 271_ PIEDL 276_ DLEGQ 281_ KLLQR 286_ IQSSE 291_ SFPKK 296_ NSGSG 301_ NADLQ 306_ NLLPK 311_ VSTML 316_ DRLHS 321_ TRQHL 326_ HQMWH 331_ VRKLK 336_ LDQCF 341_ QLRLF 346_ EQDAE 351_ KMFDW 356_ ITHNK 361_ GLFLN 366_ SYTEI 371_ GTSHP 376_ HAMEL 381_ QTQHN 386_ HFAMN 391_ CMNVY 396_ VNINR 401_ IMSVA 406_ NRLVE 411_ SGHYA 416_ SQQIR 421_ QIASQ 426_ LEQEW 431_ KAFAA 436_ ALDER 441_ STLLD 446_ MSSIF 451_ HQKAE 456_ KYMSN 461_ VDSWC 466_ KACGE 471_ VDLPS 476_ ELQDL 481_ EDAIH 486_ HHQGI 491_ YEHIT 496_ LAYSE 501_ VSQDG 506_ KSLLD 511_ KLQRP 516_ LTPGS 521_ SDSLT 526_ ASANY 531_ SKAVH 536_ HVLDV 541_ IHEVL 546_ HHQRQ 551_ LENIW 556_ QHRKV 561_ RLHQR 566_ LQLCV 571_ FQQDV 576_ QQVLD 581_ WIENH 586_ GEAFL 591_ SKHTG 596_ VGKSL 601_ HRARA 606_ LQKRH 611_ EDFEE 616_ VAQNT 621_ YTNAD 626_ KLLEA 631_ AEQLA 636_ QTGEC 641_ DPEEI 646_ YQAAH 651_ QLEDR 656_ IQDFV 661_ RRVEQ 666_ RKILL 671_ DMSVS 676_ FHTHV 681_ KELWT 686_ WLEEL 691_ QKELL 696_ DDVYA 701_ ESVEA 706_ VQDLI 711_ KRFGQ 716_ QQQTT 721_ LQVTV 726_ NVIKE 731_ GEDLI 736_ QQLRD 741_ SAISS 746_ NKTPH 751_ NSSIN 756_ HIETV 761_ LQQLD 766_ EAQSQ 771_ MEELF 776_ QERKI 781_ KLELF 786_ LQLRI 791_ FERDA 796_ IDIIS 801_ DLESW 806_ NDELS 811_ QQMND 816_ FDTED 821_ LTIAE 826_ QRLQH 831_ HADKA 836_ LTMNN 841_ LTFDV 846_ IHQGQ 851_ DLLQY 856_ VNEVQ 861_ ASGVE 866_ LLCDR 871_ DVDMA 876_ TRVQD 881_ LLEFL 886_ HEKQQ 891_ ELDLA 896_ AEQHR 901_ KHLEQ 906_ CVQLR 911_ HLQAE 916_ VKQVL 921_ GWIRN 926_ GESML 931_ NAGLI 936_ TASSL 941_ QEAEQ 946_ LQREH 951_ EQFQH 956_ AIEKT 961_ HQSAL 966_ QVQQK 971_ AEAML 976_ QANHY 981_ DMDMI 986_ RDCAE 991_ KVASH 996_ WQQLM 1001_ LKMED 1006_ RLKLV 1011_ NASVA 1016_ FYKTS 1021_ EQVCS 1026_ VLESL 1031_ EQEYK 1036_ REEDW 1041_ CGGAD 1046_ KLGPN 1051_ SETDH 1056_ VTPMI 1061_ SKHLE 1066_ QKEAF 1071_ LKACT 1076_ LARRN 1081_ ADVFL 1086_ KYLHR 1091_ NSVNM 1096_ PGMVT 1101_ HIKAP 1106_ EQQVK 1111_ NILNE 1116_ LFQRE 1121_ NRVLH 1126_ YWTMR 1131_ KRRLD 1136_ QCQQY 1141_ VVFER 1146_ SAKQA 1151_ LEWIH 1156_ DNGEF 1161_ YLSTH 1166_ TSTGS 1171_ SIQHT 1176_ QELLK 1181_ EHEEF 1186_ QITAK 1191_ QTKER 1196_ VKLLI 1201_ QLADG 1206_ FCEKG 1211_ HAHAA 1216_ EIKKC 1221_ VTAVD 1226_ KRYRD 1231_ FSLRM 1236_ EKYRT 1241_ SLEKA 1246_ LGISS 1251_ DSNKS 1256_ SKSLQ 1261_ LDIIP 1266_ ASIPG 1271_ SEVKL 1276_ RDAAH 1281_ ELNEE 1286_ KRKSA 1291_ RRKEF 1296_ IMAEL 1301_ IQTEK 1306_ AYVRD 1311_ LRECM 1316_ DTYLW 1321_ EMTSG 1326_ VEEIP 1331_ PGIVN 1336_ KELII 1341_ FGNMQ 1346_ EIYEF 1351_ HNNIF 1356_ LKELE 1361_ KYEQL 1366_ PEDVG 1371_ HCFVT 1376_ WADKF 1381_ QMYVT 1386_ YCKNK 1391_ PDSTQ 1396_ LILEH 1401_ AGSYF 1406_ DEIQQ 1411_ RHGLA 1416_ NSISS 1421_ YLIKP 1426_ VQRIT 1431_ KYQLL 1436_ LKELL 1441_ TCCEE 1446_ GKGEI 1451_ KDGLE 1456_ VMLSV 1461_ PKRAN 1466_ DAMHL 1471_ SMLEG 1476_ FDENI 1481_ ESQGE 1486_ LILQE 1491_ SFQVW 1496_ DPKTL 1501_ IRKGR 1506_ ERHLF 1511_ LFEMS 1516_ LVFSK 1521_ EVKDS 1526_ SGRSK 1531_ YLYKS 1536_ KLFTS 1541_ ELGVT 1546_ EHVEG 1551_ DPCKF 1556_ ALWVG 1561_ RTPTS 1566_ DNKIV 1571_ LKASS 1576_ IENKQ 1581_ DWIKH 1586_ IREVI 1591_ QERTI 1596_ HLKGA 1601_ LKEPI 1606_ HIPKT 1611_ APATR 1616_ QKGRR 1621_ DGEDL 1626_ DSQGD 1631_ GSSQP 1636_ DTISI 1641_ ASRTS 1646_ QNTLD 1651_ SDKLS 1656_ GGCEL 1661_ TVVIH 1666_ DFTAC 1671_ NSNEL 1676_ TIRRG 1681_ QTVEV 1686_ LERPH 1691_ DKPDW 1696_ CLVRT 1701_ TDRSP 1706_ AAEGL 1711_ VPCGS 1716_ LCIAH 1721_ SRSSM 1726_ EMEGI 1731_ FNHKD 1736_ SLSVS 1741_ SNDAS 1746_ PPASV 1751_ ASLQP 1756_ HMIGA 1761_ QSSPG 1766_ PKRPG 1771_ NTLRK 1776_ WLTSP 1781_ VRRLS 1786_ SGKAD 1791_ GHVKK 1796_ LAHKH 1801_ KKSRE 1806_ VRKSA 1811_ DAGSQ 1816_ KDSDD 1821_ SAATP 1826_ QDETV 1831_ EERGR 1836_ NEGLS 1841_ SGTLS 1846_ KSSSS 1851_ GMQSC 1856_ GEEEG 1861_ EEGAD 1866_ AVPLP 1871_ PPMAI 1876_ QQHSL 1881_ LQPDS 1886_ QDDKA 1891_ SSRLL 1896_ VRPTS 1901_ SETPS 1906_ AAELV 1911_ SAIEE 1916_ LVKSK 1921_ MALED 1926_ RPSSL 1931_ LVDQG 1936_ DSSSP 1941_ SFNPS 1946_ DNSLL 1951_ SSSSP 1956_ IDEME 1961_ ERKSS 1966_ SLKRR 1971_ HYVLQ 1976_ ELVET 1981_ ERDYV 1986_ RDLGY 1991_ VVEGY 1996_ MALMK 2001_ EDGVP 2006_ DDMKG 2011_ KDKIV 2016_ FGNIH 2021_ QIYDW 2026_ HRDFF 2031_ LGELE 2036_ KCLED 2041_ PEKLG 2046_ SLFVK 2051_ HERRL 2056_ HMYIA 2061_ YCQNK 2066_ PKSEH 2071_ IVSEY 2076_ IDTFF 2081_ EDLKQ 2086_ RLGHR 2091_ LQLTD 2096_ LLIKP 2101_ VQRIM 2106_ KYQLL 2111_ LKDFL 2116_ KYSKK 2121_ ASLDT 2126_ SELER 2131_ AVEVM 2136_ CIVPR 2141_ RCNDM 2146_ MNVGR 2151_ LQGFD 2156_ GKIVA 2161_ QGKLL 2166_ LQDTF 2171_ LVTDQ 2176_ DAGLL 2181_ PRCRE 2186_ RRIFL 2191_ FEQIV 2196_ IFSEP 2201_ LDKKK 2206_ GFSMP 2211_ GFLFK 2216_ NSIKV 2221_ SCLCL 2226_ EENVE 2231_ NDPCK 2236_ FALTS 2241_ RTGDV 2246_ VETFI 2251_ LHSSS 2256_ PSVRQ 2261_ TWIHE 2266_ INQIL 2271_ ENQRN 2276_ FLNAL 2281_ TSPIE 2286_ YQRNH 2291_ SGGGG 2296_ GGGSG 2301_ GSGGG 2306_ GGSGG 2311_ GGAPS 2316_ GGSGH 2321_ SGGPS 2326_ SCGGA 2331_ PSTSR 2336_ SRPSR 2341_ IPQPV 2346_ RHHPP 2351_ VLVSS 2356_ AASSQ 2361_ AEADK 2366_ MSGTS 2371_ TPGPS 2376_ LPPPG 2381_ AAPEA 2386_ GPSAP 2391_ SRRPP 2396_ GADAE 2401_ GSERE 2406_ AEPIP 2411_ KMKVL 2416_ ESPRK 2421_ GAANA 2426_ SGSSP 2431_ DAPAK 2436_ DARAS 2441_ LGTLP 2446_ LGKPR 2451_ AGAAS 2456_ PLNSP 2461_ LSSAV 2466_ PSLGK 2471_ EPFPP 2476_ SSPLQ 2481_ KGGSF 2486_ WSSIP 2491_ ASPAS 2496_ RPGSF 2501_ TFPGD 2506_ SDSLQ 2511_ RQTPR 2516_ HAAPG 2521_ KDTDR 2526_ MSTCS 2531_ SASEQ 2536_ SVQST 2541_ QSNGS 2546_ ESSSS 2551_ SNIST 2556_ MLVTH 2561_ DYTAV 2566_ KEDEI 2571_ NVYQG 2576_ EVVQI 2581_ LASNQ 2586_ QNMFL 2591_ VFRAA 2596_ TDQCP 2601_ AAEGW 2606_ IPGFV 2611_ LGHTS 2616_ AVIVE 2621_ NPDGT 2626_ LKKST 2631_ SWHTA 2636_ LRLRK 2641_ KSEKK 2646_ DKDGK 2651_ REGKL 2656_ ENGYR 2661_ KSREG 2666_ LSNKV 2671_ SVKLL 2676_ NPNYI 2681_ YDVPP 2686_ EFVIP 2691_ LSEVT 2696_ CETGE 2701_ TVVLR 2706_ CRVCG 2711_ RPKAS 2716_ ITWKG 2721_ PEHNT 2726_ LNNDG 2731_ HYSIS 2736_ YSDLG 2741_ EATLK 2746_ IVGVT 2751_ TEDDG 2756_ IYTCI 2761_ AVNDM 2766_ GSASS 2771_ SASLR 2776_ VLGPG 2781_ MDGIM 2786_ VTWKD 2791_ NFDSF 2796_ YSEVA 2801_ ELGRG 2806_ RFSVV 2811_ KKCDQ 2816_ KGTKR 2821_ AVATK 2826_ FVNKK 2831_ LMKRD 2836_ QVTHE 2841_ LGILQ 2846_ SLQHP 2851_ LLVGL 2856_ LDTFE 2861_ TPTSY 2866_ ILVLE 2871_ MADQG 2876_ RLLDC 2881_ VVRWG 2886_ SLTEG 2891_ KIRAH 2896_ LGEVL 2901_ EAVRY 2906_ LHNCR 2911_ IAHLD 2916_ LKPEN 2921_ ILVDE 2926_ SLAKP 2931_ TIKLA 2936_ DFGDA 2941_ VQLNT 2946_ TYYIH 2951_ QLLGN 2956_ PEFAA 2961_ PEIIL 2966_ GNPVS 2971_ LTSDT 2976_ WSVGV 2981_ LTYVL 2986_ LSGVS 2991_ PFLDD 2996_ SVEET 3001_ CLNIC 3006_ RLDFS 3011_ FPDDY 3016_ FKGVS 3021_ QKAKE 3026_ FVCFL 3031_ LQEDP 3036_ AKRPS 3041_ AALAL 3046_ QEQWL 3051_ QAGNG 3056_ RSTGV 3061_ LDTSR 3066_ LTSFI 3071_ ERRKH 3076_ QNDVR 3081_ PIRSI 3086_ KNFLQ 3091_SRLLP
1: Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases (PubMed:22155786, PubMed:27418539, PubMed:8643598). Involved in coordinating actin remodeling, which is necessary for cell migration and growth (PubMed:10341202, PubMed:22155786). Plays a key role in the regulation of neurite outgrowth and lamellipodia formation (PubMed:32109419). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (By similarity). May act as a regulator of adipogenesis (By similarity)