Glutaredoxin-3 (PKC-interacting cousin of thioredoxin) (PICOT) (PKC-theta-interacting protein) (PKCq-interacting protein) (Thioredoxin-like protein 2)
1_MAAGA 6_ AEAAV 11_ AAVEE 16_ VGSAG 21_ QFEEL 26_ LRLKA 31_ KSLLV 36_ VHFWA 41_ PWAPQ 46_ CAQMN 51_ EVMAE 56_ LAKEL 61_ PQVSF 66_ VKLEA 71_ EGVPE 76_ VSEKY 81_ EISSV 86_ PTFLF 91_ FKNSQ 96_ KIDRL 101_ DGAHA 106_ PELTK 111_ KVQRH 116_ ASSGS 121_ FLPSA 126_ NEHLK 131_ EDLNL 136_ RLKKL 141_ THAAP 146_ CMLFM 151_ KGTPQ 156_ EPRCG 161_ FSKQM 166_ VEILH 171_ KHNIQ 176_ FSSFD 181_ IFSDE 186_ EVRQG 191_ LKAYS 196_ SWPTY 201_ PQLYV 206_ SGELI 211_ GGLDI 216_ IKELE 221_ ASEEL 226_ DTICP 231_ KAPKL 236_ EERLK 241_ VLTNK 246_ ASVML 251_ FMKGN 256_ KQEAK 261_ CGFSK 266_ QILEI 271_ LNSTG 276_ VEYET 281_ FDILE 286_ DEEVR 291_ QGLKA 296_ YSNWP 301_ TYPQL 306_ YVKGE 311_ LVGGL 316_ DIVKE 321_ LKENG 326_ELLPI
1: Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (PubMed:26613676, PubMed:27519415). Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). Required for hemoglobin maturation (PubMed:23615448). Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity