Gene name: WFS1

Uniprot entry:

O76024

Protein names:

Wolframin

Protein sequence:

1_MDSNT 6_ APLGP 11_ SCPQP 16_ PPAPQ 21_ PQARS 26_ RLNAT 31_ ASLEQ 36_ ERSER 41_ PRAPG 46_ PQAGP 51_ GPGVR 56_ DAAAP 61_ AEPQA 66_ QHTRS 71_ RERAD 76_ GTGPT 81_ KGDME 86_ IPFEE 91_ VLERA 96_ KAGDP 101_ KAQTE 106_ VGKHY 111_ LQLAG 116_ DTDEE 121_ LNSCT 126_ AVDWL 131_ VLAAK 136_ QGRRE 141_ AVKLL 146_ RRCLA 151_ DRRGI 156_ TSENE 161_ REVRQ 166_ LSSET 171_ DLERA 176_ VRKAA 181_ LVMYW 186_ KLNPK 191_ KKKQV 196_ AVAEL 201_ LENVG 206_ QVNEH 211_ DGGAQ 216_ PGPVP 221_ KSLQK 226_ QRRML 231_ ERLVS 236_ SESKN 241_ YIALD 246_ DFVEI 251_ TKKYA 256_ KGVIP 261_ SSLFL 266_ QDDED 271_ DDELA 276_ GKSPE 281_ DLPLR 286_ LKVVK 291_ YPLHA 296_ IMEIK 301_ EYLID 306_ MASRA 311_ GMHWL 316_ STIIP 321_ THHIN 326_ ALIFF 331_ FIVSN 336_ LTIDF 341_ FAFFI 346_ PLVIF 351_ YLSFI 356_ SMVIC 361_ TLKVF 366_ QDSKA 371_ WENFR 376_ TLTDL 381_ LLRFE 386_ PNLDV 391_ EQAEV 396_ NFGWN 401_ HLEPY 406_ AHFLL 411_ SVFFV 416_ IFSFP 421_ IASKD 426_ CIPCS 431_ ELAVI 436_ TGFFT 441_ VTSYL 446_ SLSTH 451_ AEPYT 456_ RRALA 461_ TEVTA 466_ GLLSL 471_ LPSMP 476_ LNWPY 481_ LKVLG 486_ QTFIT 491_ VPVGH 496_ LVVLN 501_ VSVPC 506_ LLYVY 511_ LLYLF 516_ FRMAQ 521_ LRNFK 526_ GTYCY 531_ LVPYL 536_ VCFMW 541_ CELSV 546_ VILLE 551_ STGLG 556_ LLRAS 561_ IGYFL 566_ FLFAL 571_ PILVA 576_ GLALV 581_ GVLQF 586_ ARWFT 591_ SLELT 596_ KIAVT 601_ VAVCS 606_ VPLLL 611_ RWWTK 616_ ASFSV 621_ VGMVK 626_ SLTRS 631_ SMVKL 636_ ILVWL 641_ TAIVL 646_ FCWFY 651_ VYRSE 656_ GMKVY 661_ NSTLT 666_ WQQYG 671_ ALCGP 676_ RAWKE 681_ TNMAR 686_ TQILC 691_ SHLEG 696_ HRVTW 701_ TGRFK 706_ YVRVT 711_ DIDNS 716_ AESAI 721_ NMLPF 726_ FIGDW 731_ MRCLY 736_ GEAYP 741_ ACSPG 746_ NTSTA 751_ EEELC 756_ RLKLL 761_ AKHPC 766_ HIKKF 771_ DRYKF 776_ EITVG 781_ MPFSS 786_ GADGS 791_ RSREE 796_ DDVTK 801_ DIVLR 806_ ASSEF 811_ KSVLL 816_ SLRQG 821_ SLIEF 826_ STILE 831_ GRLGS 836_ KWPVF 841_ ELKAI 846_ SCLNC 851_ MAQLS 856_ PTRRH 861_ VKIEH 866_ DWRST 871_ VHGAV 876_ KFAFD 881_FFFFP

Protein annotations

Protein functions:

1: Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store (PubMed:16989814). Negatively regulates the ER stress response and positively regulates the stability of V-ATPase subunits ATP6V1A and ATP1B1 by preventing their degradation through an unknown proteasome-independent mechanism (PubMed:23035048)