E3 ubiquitin-protein ligase NEURL1 (EC 2.3.2.27) (Neuralized-like protein 1A) (h-neu) (h-neuralized 1) (RING finger protein 67) (RING-type E3 ubiquitin transferase NEURL1)
1_MGNNF 6_ SSIPS 11_ LPRGN 16_ PSRAP 21_ RGHPQ 26_ NLKDS 31_ IGGPF 36_ PVTSH 41_ RCHHK 46_ QKHCP 51_ AVLPS 56_ GGLPA 61_ TPLLF 66_ HPHTK 71_ GSQIL 76_ MDLSH 81_ KAVKR 86_ QASFC 91_ NAITF 96_ SNRPV 101_ LIYEQ 106_ VRLKI 111_ TKKQC 116_ CWSGA 121_ LRLGF 126_ TSKDP 131_ SRIHP 136_ DSLPK 141_ YACPD 146_ LVSQS 151_ GFWAK 156_ ALPEE 161_ FANEG 166_ NIIAF 171_ WVDKK 176_ GRVFH 181_ RINDS 186_ AVMLF 191_ FSGVR 196_ TADPL 201_ WALVD 206_ VYGLT 211_ RGVQL 216_ LDSEL 221_ VLPDC 226_ LRPRS 231_ FTALR 236_ RPSLR 241_ READD 246_ ARLSV 251_ SLCDL 256_ NVPGA 261_ DGDEA 266_ APAAG 271_ CPIPQ 276_ NSLNS 281_ QHSRA 286_ LPAQL 291_ DGDLR 296_ FHALR 301_ AGAHV 306_ RILDE 311_ QTVAR 316_ VEHGR 321_ DERAL 326_ VFTSR 331_ PVRVA 336_ ETIFV 341_ KVTRS 346_ GGARP 351_ GALSF 356_ GVTTC 361_ DPGTL 366_ RPADL 371_ PFSPE 376_ ALVDR 381_ KEFWA 386_ VCRVP 391_ GPLHS 396_ GDILG 401_ LVVNA 406_ DGELH 411_ LSHNG 416_ AAAGM 421_ QLCVD 426_ ASQPL 431_ WMLFG 436_ LHGTI 441_ TQIRI 446_ LGSTI 451_ LAERG 456_ IPSLP 461_ CSPAS 466_ TPTSP 471_ SALGS 476_ RLSDP 481_ LLSTC 486_ SSGPL 491_ GSSAG 496_ GTAPN 501_ SPVSL 506_ PESPV 511_ TPGLG 516_ QWSDE 521_ CTICY 526_ EHAVD 531_ TVIYT 536_ CGHMC 541_ LCYAC 546_ GLRLK 551_ KALHA 556_ CCPIC 561_ RRPIK 566_DIIKT
1: Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element-binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor; inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway