SEC14-like protein 2 (Alpha-tocopherol-associated protein) (TAP) (hTAP) (Squalene transfer protein) (Supernatant protein factor) (SPF)
1_MSGRV 6_ GDLSP 11_ RQKEA 16_ LAKFR 21_ ENVQD 26_ VLPAL 31_ PNPDD 36_ YFLLR 41_ WLRAR 46_ SFDLQ 51_ KSEAM 56_ LRKHV 61_ EFRKQ 66_ KDIDN 71_ IISWQ 76_ PPEVI 81_ QQYLS 86_ GGMCG 91_ YDLDG 96_ CPVWY 101_ DIIGP 106_ LDAKG 111_ LLFSA 116_ SKQDL 121_ LRTKM 126_ RECEL 131_ LLQEC 136_ AHQTT 141_ KLGRK 146_ VETIT 151_ IIYDC 156_ EGLGL 161_ KHLWK 166_ PAVEA 171_ YGEFL 176_ CMFEE 181_ NYPET 186_ LKRLF 191_ VVKAP 196_ KLFPV 201_ AYNLI 206_ KPFLS 211_ EDTRK 216_ KIMVL 221_ GANWK 226_ EVLLK 231_ HISPD 236_ QVPVE 241_ YGGTM 246_ TDPDG 251_ NPKCK 256_ SKINY 261_ GGDIP 266_ RKYYV 271_ RDQVK 276_ QQYEH 281_ SVQIS 286_ RGSSH 291_ QVEYE 296_ ILFPG 301_ CVLRW 306_ QFMSD 311_ GADVG 316_ FGIFL 321_ KTKMG 326_ ERQRA 331_ GEMTE 336_ VLPNQ 341_ RYNSH 346_ LVPED 351_ GTLTC 356_ SDPGI 361_ YVLRF 366_ DNTYS 371_ FIHAK 376_ KVNFT 381_ VEVLL 386_ PDKAS 391_ EEKMK 396_QLGAG
1: Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell