Probable cytosolic iron-sulfur protein assembly protein CIAO1 (WD repeat-containing protein 39)
1_MKDSL 6_ VLLGR 11_ VPAHP 16_ DSRCW 21_ FLAWN 26_ PAGTL 31_ LASCG 36_ GDRRI 41_ RIWGT 46_ EGDSW 51_ ICKSV 56_ LSEGH 61_ QRTVR 66_ KVAWS 71_ PCGNY 76_ LASAS 81_ FDATT 86_ CIWKK 91_ NQDDF 96_ ECVTT 101_ LEGHE 106_ NEVKS 111_ VAWAP 116_ SGNLL 121_ ATCSR 126_ DKSVW 131_ VWEVD 136_ EEDEY 141_ ECVSV 146_ LNSHT 151_ QDVKH 156_ VVWHP 161_ SQELL 166_ ASASY 171_ DDTVK 176_ LYREE 181_ EDDWV 186_ CCATL 191_ EGHES 196_ TVWSL 201_ AFDPS 206_ GQRLA 211_ SCSDD 216_ RTVRI 221_ WRQYL 226_ PGNEQ 231_ GVACS 236_ GSDPS 241_ WKCIC 246_ TLSGF 251_ HSRTI 256_ YDIAW 261_ CQLTG 266_ ALATA 271_ CGDDA 276_ IRVFQ 281_ EDPNS 286_ DPQQP 291_ TFSLT 296_ AHLHQ 301_ AHSQD 306_ VNCVA 311_ WNPKE 316_ PGLLA 321_ SCSDD 326_ GEVAF 331_WKYQR
1: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins (PubMed:17937914, PubMed:23891004, PubMed:38950322). As a CIA complex component, interacts specifically with CIAO2A or CIAO2B and MMS19 to assist different branches of iron-sulfur protein assembly, depending of its interactors. The complex CIAO1:CIAO2B:MMS19 binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. CIAO1:CIAO2A specifically matures ACO1 and stabilizes IREB2 (PubMed:23891004). Seems to specifically modulate the transactivation activity of WT1 (PubMed:9556563). As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation (PubMed:20797633)