AN1-type zinc finger protein 5 (Zinc finger A20 domain-containing protein 2) (Zinc finger protein 216)
1_MAQET 6_ NQTPG 11_ PMLCS 16_ TGCGF 21_ YGNPR 26_ TNGMC 31_ SVCYK 36_ EHLQR 41_ QQNSG 46_ RMSPM 51_ GTASG 56_ SNSPT 61_ SDSAS 66_ VQRAD 71_ TSLNN 76_ CEGAA 81_ GSTSE 86_ KSRNV 91_ PVAAL 96_ PVTQQ 101_ MTEMS 106_ ISRED 111_ KITTP 116_ KTEVS 121_ EPVVT 126_ QPSPS 131_ VSQPS 136_ TSQSE 141_ EKAPE 146_ LPKPK 151_ KNRCF 156_ MCRKK 161_ VGLTG 166_ FDCRC 171_ GNLFC 176_ GLHRY 181_ SDKHN 186_ CPYDY 191_ KAEAA 196_ AKIRK 201_ ENPVV 206_VAEKI
1: Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Also inhibits tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation