Regulator of G-protein signaling 20 (RGS20) (Gz-selective GTPase-activating protein) (G(z)GAP) (Gz-GAP) (Regulator of G-protein signaling Z1) (Regulator of Gz-selective protein signaling 1)
1_MPQLS 6_ QDNQE 11_ CLQKH 16_ FSRPS 21_ IWTQF 26_ LPLFR 31_ AQRYN 36_ TDIHQ 41_ ITENE 46_ GDLRA 51_ VPDIK 56_ SFPPA 61_ QLPDS 66_ PAAPK 71_ LFGLL 76_ SSPLS 81_ SLARF 86_ FSHLL 91_ RRPPP 96_ EAPRR 101_ RLDFS 106_ PLLPA 111_ LPAAR 116_ LSRGH 121_ EELPG 126_ RLSLL 131_ LGAAL 136_ ALPGR 141_ PSGGR 146_ PLRPP 151_ HPVAK 156_ PREED 161_ ATAGQ 166_ SSPMP 171_ QMGSE 176_ RMEMR 181_ KRQMP 186_ AAQDT 191_ PGAAP 196_ GQPGA 201_ GSRGS 206_ NACCF 211_ CWCCC 216_ CSCSC 221_ LTVRN 226_ QEDQR 231_ PTIAS 236_ HELRA 241_ DLPTW 246_ EESPA 251_ PTLEE 256_ VNAWA 261_ QSFDK 266_ LMVTP 271_ AGRNA 276_ FREFL 281_ RTEFS 286_ EENML 291_ FWMAC 296_ EELKK 301_ EANKN 306_ IIEEK 311_ ARIIY 316_ EDYIS 321_ ILSPK 326_ EVSLD 331_ SRVRE 336_ VINRN 341_ MVEPS 346_ QHIFD 351_ DAQLQ 356_ IYTLM 361_ HRDSY 366_ PRFMN 371_ SAVYK 376_ DLLQS 381_LSEKS
1: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity)