Solute carrier family 22 member 5 (High-affinity sodium-dependent carnitine cotransporter) (Organic cation/carnitine transporter 2)
1_MRDYD 6_ EVTAF 11_ LGEWG 16_ PFQRL 21_ IFFLL 26_ SASII 31_ PNGFT 36_ GLSSV 41_ FLIAT 46_ PEHRC 51_ RVPDA 56_ ANLSS 61_ AWRNH 66_ TVPLR 71_ LRDGR 76_ EVPHS 81_ CRRYR 86_ LATIA 91_ NFSAL 96_ GLEPG 101_ RDVDL 106_ GQLEQ 111_ ESCLD 116_ GWEFS 121_ QDVYL 126_ STIVT 131_ EWNLV 136_ CEDDW 141_ KAPLT 146_ ISLFF 151_ VGVLL 156_ GSFIS 161_ GQLSD 166_ RFGRK 171_ NVLFV 176_ TMGMQ 181_ TGFSF 186_ LQIFS 191_ KNFEM 196_ FVVLF 201_ VLVGM 206_ GQISN 211_ YVAAF 216_ VLGTE 221_ ILGKS 226_ VRIIF 231_ STLGV 236_ CIFYA 241_ FGYMV 246_ LPLFA 251_ YFIRD 256_ WRMLL 261_ VALTM 266_ PGVLC 271_ VALWW 276_ FIPES 281_ PRWLI 286_ SQGRF 291_ EEAEV 296_ IIRKA 301_ AKANG 306_ IVVPS 311_ TIFDP 316_ SELQD 321_ LSSKK 326_ QQSHN 331_ ILDLL 336_ RTWNI 341_ RMVTI 346_ MSIML 351_ WMTIS 356_ VGYFG 361_ LSLDT 366_ PNLHG 371_ DIFVN 376_ CFLSA 381_ MVEVP 386_ AYVLA 391_ WLLLQ 396_ YLPRR 401_ YSMAT 406_ ALFLG 411_ GSVLL 416_ FMQLV 421_ PPDLY 426_ YLATV 431_ LVMVG 436_ KFGVT 441_ AAFSM 446_ VYVYT 451_ AELYP 456_ TVVRN 461_ MGVGV 466_ SSTAS 471_ RLGSI 476_ LSPYF 481_ VYLGA 486_ YDRFL 491_ PYILM 496_ GSLTI 501_ LTAIL 506_ TLFLP 511_ ESFGT 516_ PLPDT 521_ IDQML 526_ RVKGM 531_ KHRKT 536_ PSHTR 541_ MLKDG 546_ QERPT 551_ILKST
1: Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine (PubMed:10454528, PubMed:10525100, PubMed:10966938, PubMed:17509700, PubMed:20722056, PubMed:33124720). Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 11.3 (PubMed:10454528, PubMed:10525100, PubMed:10966938). In intestinal epithelia, transports the quorum-sensing pentapeptide CSF (competence and sporulation factor) from B.subtilis which induces cytoprotective heat shock proteins contributing to intestinal homeostasis (PubMed:18005709). May also contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (Probable)
2: Retained in the ER, unable to perform carnitine uptake