Bestrophin-1 (TU15B) (Vitelliform macular dystrophy protein 2)
1_MTITY 6_ TSQVA 11_ NARLG 16_ SFSRL 21_ LLCWR 26_ GSIYK 31_ LLYGE 36_ FLIFL 41_ LCYYI 46_ IRFIY 51_ RLALT 56_ EEQQL 61_ MFEKL 66_ TLYCD 71_ SYIQL 76_ IPISF 81_ VLGFY 86_ VTLVV 91_ TRWWN 96_ QYENL 101_ PWPDR 106_ LMSLV 111_ SGFVE 116_ GKDEQ 121_ GRLLR 126_ RTLIR 131_ YANLG 136_ NVLIL 141_ RSVST 146_ AVYKR 151_ FPSAQ 156_ HLVQA 161_ GFMTP 166_ AEHKQ 171_ LEKLS 176_ LPHNM 181_ FWVPW 186_ VWFAN 191_ LSMKA 196_ WLGGR 201_ IRDPI 206_ LLQSL 211_ LNEMN 216_ TLRTQ 221_ CGHLY 226_ AYDWI 231_ SIPLV 236_ YTQVV 241_ TVAVY 246_ SFFLT 251_ CLVGR 256_ QFLNP 261_ AKAYP 266_ GHELD 271_ LVVPV 276_ FTFLQ 281_ FFFYV 286_ GWLKV 291_ AEQLI 296_ NPFGE 301_ DDDDF 306_ ETNWI 311_ VDRNL 316_ QVSLL 321_ AVDEM 326_ HQDLP 331_ RMEPD 336_ MYWNK 341_ PEPQP 346_ PYTAA 351_ SAQFR 356_ RASFM 361_ GSTFN 366_ ISLNK 371_ EEMEF 376_ QPNQE 381_ DEEDA 386_ HAGII 391_ GRFLG 396_ LQSHD 401_ HHPPR 406_ ANSRT 411_ KLLWP 416_ KRESL 421_ LHEGL 426_ PKNHK 431_ AAKQN 436_ VRGQE 441_ DNKAW 446_ KLKAV 451_ DAFKS 456_ APLYQ 461_ RPGYY 466_ SAPQT 471_ PLSPT 476_ PMFFP 481_ LEPSA 486_ PSKLH 491_ SVTGI 496_ DTKDK 501_ SLKTV 506_ SSGAK 511_ KSFEL 516_ LSESD 521_ GALME 526_ HPEVS 531_ QVRRK 536_ TVEFN 541_ LTDMP 546_ EIPEN 551_ HLKEP 556_ LEQSP 561_ TNIHT 566_ TLKDH 571_ MDPYW 576_ALENR
1: Ligand-gated anion channel that allows the movement of anions across cell membranes when activated by calcium (Ca2+) (PubMed:11904445, PubMed:12907679, PubMed:18179881, PubMed:18400985, PubMed:19853238, PubMed:21330666, PubMed:26200502, PubMed:26720466, PubMed:35789156). Allows the movement of chloride and hydrogencarbonate (PubMed:11904445, PubMed:12907679, PubMed:18179881, PubMed:18400985, PubMed:19853238, PubMed:21330666, PubMed:26200502, PubMed:26720466, PubMed:35789156). Found in a partially open conformation leading to significantly smaller chloride movement (PubMed:35789156). Upon F2R/PAR-1 activation, the sequestered calcium is released into the cytosol of astrocytes, leading to the (Ca2+)-dependent release of L-glutamate into the synaptic cleft that targets the neuronal postsynaptic GRIN2A/NMDAR receptor resulting in the synaptic plasticity regulation (By similarity). Upon activation of the norepinephrine-alpha-1 adrenergic receptor signaling pathway, transports as well D-serine than L-glutamate in a (Ca2+)-dependent manner, leading to activation of adjacent NMDAR receptors and therefore regulates the heterosynaptic long-term depression and metaplasticity during initial memory acquisition (By similarity). Releases the 4-aminobutanoate neurotransmitter in a (Ca2+)-dependent manner, and participates in its tonic release from cerebellar glial cells (By similarity)