Protein JTB (Jumping translocation breakpoint protein) (Prostate androgen-regulated protein) (PAR protein)
1_MLAGA 6_ GRPGL 11_ PQGRH 16_ LCWLL 21_ CAFTL 26_ KLCQA 31_ EAPVQ 36_ EEKLS 41_ ASTSN 46_ LPCWL 51_ VEEFV 56_ VAEEC 61_ SPCSN 66_ FRAKT 71_ TPECG 76_ PTGYV 81_ EKITC 86_ SSSKR 91_ NEFKS 96_ CRSAL 101_ MEQRL 106_ FWKFE 111_ GAVVC 116_ VALIF 121_ ACLVI 126_ IRQRQ 131_ LDRKA 136_ LEKVR 141_KQIES
1: Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity)