Transient receptor potential cation channel subfamily M member 2 (Estrogen-responsive element-associated gene 1 protein) (Long transient receptor potential channel 2) (LTrpC-2) (LTrpC2) (Transient receptor potential channel 7) (TrpC7) (Transient receptor potential melastatin 2)
1_MEPSA 6_ LRKAG 11_ SEQEE 16_ GFEGL 21_ PRRVT 26_ DLGMV 31_ SNLRR 36_ SNSSL 41_ FKSWR 46_ LQCPF 51_ GNNDK 56_ QESLS 61_ SWIPE 66_ NIKKK 71_ ECVYF 76_ VESSK 81_ LSDAG 86_ KVVCQ 91_ CGYTH 96_ EQHLE 101_ EATKP 106_ HTFQG 111_ TQWDP 116_ KKHVQ 121_ EMPTD 126_ AFGDI 131_ VFTGL 136_ SQKVK 141_ KYVRV 146_ SQDTP 151_ SSVIY 156_ HLMTQ 161_ HWGLD 166_ VPNLL 171_ ISVTG 176_ GAKNF 181_ NMKPR 186_ LKSIF 191_ RRGLV 196_ KVAQT 201_ TGAWI 206_ ITGGS 211_ HTGVM 216_ KQVGE 221_ AVRDF 226_ SLSSS 231_ YKEGE 236_ LITIG 241_ VATWG 246_ TVHRR 251_ EGLIH 256_ PTGSF 261_ PAEYI 266_ LDEDG 271_ QGNLT 276_ CLDSN 281_ HSHFI 286_ LVDDG 291_ THGQY 296_ GVEIP 301_ LRTRL 306_ EKFIS 311_ EQTKE 316_ RGGVA 321_ IKIPI 326_ VCVVL 331_ EGGPG 336_ TLHTI 341_ DNATT 346_ NGTPC 351_ VVVEG 356_ SGRVA 361_ DVIAQ 366_ VANLP 371_ VSDIT 376_ ISLIQ 381_ QKLSV 386_ FFQEM 391_ FETFT 396_ ESRIV 401_ EWTKK 406_ IQDIV 411_ RRRQL 416_ LTVFR 421_ EGKDG 426_ QQDVD 431_ VAILQ 436_ ALLKA 441_ SRSQD 446_ HFGHE 451_ NWDHQ 456_ LKLAV 461_ AWNRV 466_ DIARS 471_ EIFMD 476_ EWQWK 481_ PSDLH 486_ PTMTA 491_ ALISN 496_ KPEFV 501_ KLFLE 506_ NGVQL 511_ KEFVT 516_ WDTLL 521_ YLYEN 526_ LDPSC 531_ LFHSK 536_ LQKVL 541_ VEDPE 546_ RPACA 551_ PAAPR 556_ LQMHH 561_ VAQVL 566_ RELLG 571_ DFTQP 576_ LYPRP 581_ RHNDR 586_ LRLLL 591_ PVPHV 596_ KLNVQ 601_ GVSLR 606_ SLYKR 611_ SSGHV 616_ TFTMD 621_ PIRDL 626_ LIWAI 631_ VQNRR 636_ ELAGI 641_ IWAQS 646_ QDCIA 651_ AALAC 656_ SKILK 661_ ELSKE 666_ EEDTD 671_ SSEEM 676_ LALAE 681_ EYEHR 686_ AIGVF 691_ TECYR 696_ KDEER 701_ AQKLL 706_ TRVSE 711_ AWGKT 716_ TCLQL 721_ ALEAK 726_ DMKFV 731_ SHGGI 736_ QAFLT 741_ KVWWG 746_ QLSVD 751_ NGLWR 756_ VTLCM 761_ LAFPL 766_ LLTGL 771_ ISFRE 776_ KRLQD 781_ VGTPA 786_ ARARA 791_ FFTAP 796_ VVVFH 801_ LNILS 806_ YFAFL 811_ CLFAY 816_ VLMVD 821_ FQPVP 826_ SWCEC 831_ AIYLW 836_ LFSLV 841_ CEEMR 846_ QLFYD 851_ PDECG 856_ LMKKA 861_ ALYFS 866_ DFWNK 871_ LDVGA 876_ ILLFV 881_ AGLTC 886_ RLIPA 891_ TLYPG 896_ RVILS 901_ LDFIL 906_ FCLRL 911_ MHIFT 916_ ISKTL 921_ GPKII 926_ IVKRM 931_ MKDVF 936_ FFLFL 941_ LAVWV 946_ VSFGV 951_ AKQAI 956_ LIHNE 961_ RRVDW 966_ LFRGA 971_ VYHSY 976_ LTIFG 981_ QIPGY 986_ IDGVN 991_ FNPEH 996_ CSPNG 1001_ TDPYK 1006_ PKCPE 1011_ SDATQ 1016_ QRPAF 1021_ PEWLT 1026_ VLLLC 1031_ LYLLF 1036_ TNILL 1041_ LNLLI 1046_ AMFNY 1051_ TFQQV 1056_ QEHTD 1061_ QIWKF 1066_ QRHDL 1071_ IEEYH 1076_ GRPAA 1081_ PPPFI 1086_ LLSHL 1091_ QLFIK 1096_ RVVLK 1101_ TPAKR 1106_ HKQLK 1111_ NKLEK 1116_ NEEAA 1121_ LLSWE 1126_ IYLKE 1131_ NYLQN 1136_ RQFQQ 1141_ KQRPE 1146_ QKIED 1151_ ISNKV 1156_ DAMVD 1161_ LLDLD 1166_ PLKRS 1171_ GSMEQ 1176_ RLASL 1181_ EEQVA 1186_ QTAQA 1191_ LHWIV 1196_ RTLRA 1201_ SGFSS 1206_ EADVP 1211_ TLASQ 1216_ KAAEE 1221_ PDAEP 1226_ GGRKK 1231_ TEEPG 1236_ DSYHV 1241_ NARHL 1246_ LYPNC 1251_ PVTRF 1256_ PVPNE 1261_ KVPWE 1266_ TEFLI 1271_ YDPPF 1276_ YTAER 1281_ KDAAA 1286_ MDPMG 1291_ DTLEP 1296_ LSTIQ 1301_ YNVVD 1306_ GLRDR 1311_ RSFHG 1316_ PYTVQ 1321_ AGLPL 1326_ NPMGR 1331_ TGLRG 1336_ RGSLS 1341_ CFGPN 1346_ HTLYP 1351_ MVTRW 1356_ RRNED 1361_ GAICR 1366_ KSIKK 1371_ MLEVL 1376_ VVKLP 1381_ LSEHW 1386_ ALPGG 1391_ SREPG 1396_ EMLPR 1401_ KLKRI 1406_ LRQEH 1411_ WPSFE 1416_ NLLKC 1421_ GMEVY 1426_ KGYMD 1431_ DPRNT 1436_ DNAWI 1441_ ETVAV 1446_ SVHFQ 1451_ DQNDV 1456_ ELNRL 1461_ NSNLH 1466_ ACDSG 1471_ ASIRW 1476_ QVVDR 1481_ RIPLY 1486_ ANHKT 1491_ LLQKA 1496_AAEFG
1: Nonselective, voltage-independent cation channel that mediates Na(+) and Ca(2+) influx, leading to increased cytoplasmic Ca(2+) levels (PubMed:11385575, PubMed:11509734, PubMed:11804595, PubMed:12594222, PubMed:15561722, PubMed:16601673, PubMed:19171771, PubMed:20660597, PubMed:25620041, PubMed:27068538, PubMed:27383051, PubMed:28775320, PubMed:29745897, PubMed:30467180, PubMed:31513012, PubMed:34788616). Functions as a ligand-gated ion channel, gated by intracellular adenosine diphosphate ribose (ADP-ribose), Ca(2+), warm temperature, and oxidative stress (PubMed:19171771, PubMed:25620041, PubMed:28775320, PubMed:30467180). The precise physiological activators are under debate; the true, physiological activators may be ADP-ribose and ADP-ribose-2'-phosphate (PubMed:20650899, PubMed:25918360). Binding of ADP-ribose to the cytoplasmic Nudix domain causes a conformation change; the channel is primed but still requires Ca(2+) binding to trigger channel opening (PubMed:19171771, PubMed:25620041, PubMed:28775320, PubMed:29745897, PubMed:30467180). Extracellular Ca(2+) passes through the channel and increases channel activity (PubMed:19171771). Contributes to Ca(2+) release from intracellular stores in response to ADP-ribose (PubMed:19454650). Plays a role in numerous processes that involve signaling via intracellular Ca(2+) levels (Probable). Besides, mediates the release of lysosomal Zn(2+) stores in response to reactive oxygen species, leading to increased cytosolic Zn(2+) levels (PubMed:25562606, PubMed:27068538). Plays a role in mediating behavorial and physiological responses to moderate heat and thereby contributes to body temperature homeostasis. Plays a role in insulin secretion, a process that requires increased cytoplasmic Ca(2+) levels (By similarity). Required for normal IFNG and cytokine secretion and normal innate immune immunity in response to bacterial infection. Required for normal phagocytosis and cytokine release by macrophages exposed to zymosan (in vitro) (PubMed:22493272). Plays a role in dendritic cell differentiation and maturation, and in dendritic cell chemotaxis via its role in regulating cytoplasmic Ca(2+) levels (By similarity). Plays a role in the regulation of the reorganization of the actin cytoskeleton and filopodia formation in response to reactive oxygen species via its role in increasing cytoplasmic Ca(2+) and Zn(2+) levels (PubMed:27068538). Confers susceptibility to cell death following oxidative stress (PubMed:12594222, PubMed:25562606)
2: Lacks cation channel activity. Does not mediate cation transport in response to oxidative stress or ADP-ribose
3: Lacks cation channel activity and negatively regulates the channel activity of isoform 1. Negatively regulates susceptibility to cell death in reposponse to oxidative stress