ATP-dependent DNA helicase Q5 (EC 3.6.4.12) (DNA helicase, RecQ-like type 5) (RecQ5) (RecQ protein-like 5)
1_MSSHH 6_ TTFPF 11_ DPERR 16_ VRSTL 21_ KKVFG 26_ FDSFK 31_ TPLQE 36_ SATMA 41_ VVKGN 46_ KDVFV 51_ CMPTG 56_ AGKSL 61_ CYQLP 66_ ALLAK 71_ GITIV 76_ VSPLI 81_ ALIQD 86_ QVDHL 91_ LTLKV 96_ RVSSL 101_ NSKLS 106_ AQERK 111_ ELLAD 116_ LEREK 121_ PQTKI 126_ LYITP 131_ EMAAS 136_ SSFQP 141_ TLNSL 146_ VSRHL 151_ LSYLV 156_ VDEAH 161_ CVSQW 166_ GHDFR 171_ PDYLR 176_ LGALR 181_ SRLGH 186_ APCVA 191_ LTATA 196_ TPQVQ 201_ EDVFA 206_ ALHLK 211_ KPVAI 216_ FKTPC 221_ FRANL 226_ FYDVQ 231_ FKELI 236_ SDPYG 241_ NLKDF 246_ CLKAL 251_ GQEAD 256_ KGLSG 261_ CGIVY 266_ CRTRE 271_ ACEQL 276_ AIELS 281_ CRGVN 286_ AKAYH 291_ AGLKA 296_ SERTL 301_ VQNDW 306_ MEEKV 311_ PVIVA 316_ TISFG 321_ MGVDK 326_ ANVRF 331_ VAHWN 336_ IAKSM 341_ AGYYQ 346_ ESGRA 351_ GRDGK 356_ PSWCR 361_ LYYSR 366_ NDRDQ 371_ VSFLI 376_ RKEVA 381_ KLQEK 386_ RGNKA 391_ SDKAT 396_ IMAFD 401_ ALVTF 406_ CEELG 411_ CRHAA 416_ IAKYF 421_ GDALP 426_ ACAKG 431_ CDHCQ 436_ NPTAV 441_ RRRLE 446_ ALERS 451_ SSWSK 456_ TCIGP 461_ SQGNG 466_ FDPEL 471_ YEGGR 476_ KGYGD 481_ FSRYD 486_ EGSGG 491_ SGDEG 496_ RDEAH 501_ KREWN 506_ LFYQK 511_ QMQLR 516_ KGKDP 521_ KIEEF 526_ VPPDE 531_ NCPLK 536_ EASSR 541_ RIPRL 546_ TVKAR 551_ EHCLR 556_ LLEEA 561_ LSSNR 566_ QSTRT 571_ ADEAD 576_ LRAKA 581_ VELEH 586_ ETFRN 591_ AKVAN 596_ LYKAS 601_ VLKKV 606_ ADIHR 611_ ASKDG 616_ QPYDM 621_ GGSAK 626_ SCSAQ 631_ AEPPE 636_ PNEYD 641_ IPPAS 646_ HVYSL 651_ KPKRV 656_ GAGFP 661_ KGSCP 666_ FQTAT 671_ ELMET 676_ TRIRE 681_ QAPQP 686_ ERGGE 691_ HEPPS 696_ RPCGL 701_ LDEDG 706_ SEPLP 711_ GPRGE 716_ VPGGS 721_ AHYGG 726_ PSPEK 731_ KAKSS 736_ SGGSS 741_ LAKGR 746_ ASKKQ 751_ QLLAT 756_ AAHKD 761_ SQSIA 766_ RFFCR 771_ RVESP 776_ ALLAS 781_ APEAE 786_ GACPS 791_ CEGVQ 796_ GPPMA 801_ PEKYT 806_ GEEDG 811_ AGGHS 816_ PAPPQ 821_ TEECL 826_ RERPS 831_ TCPPR 836_ DQGTP 841_ EVQPT 846_ PAKDT 851_ WKGKR 856_ PRSQQ 861_ ENPES 866_ QPQKR 871_ PRPSA 876_ KPSVV 881_ AEVKG 886_ SVSAS 891_ EQGTL 896_ NPTAQ 901_ DPFQL 906_ SAPGV 911_ SLKEA 916_ ANVVV 921_ KCLTP 926_ FYKEG 931_ KFASK 936_ ELFKG 941_ FARHL 946_ SHLLT 951_ QKTSP 956_ GRSVK 961_ EEAQN 966_ LIRHF 971_ FHGRA 976_ RCESE 981_ ADWHG 986_LCGPQ
1: DNA helicase that plays an important role in DNA replication, transcription and repair (PubMed:20643585, PubMed:22973052, PubMed:28100692). Probably unwinds DNA in a 3'-5' direction (Probable) (PubMed:28100692). Binds to the RNA polymerase II subunit POLR2A during transcription elongation and suppresses transcription-associated genomic instability (PubMed:20231364). Also associates with POLR1A and enforces the stability of ribosomal DNA arrays (PubMed:27502483). Plays an important role in mitotic chromosome separation after cross-over events and cell cycle progress (PubMed:22013166). Mechanistically, removes RAD51 filaments protecting stalled replication forks at common fragile sites and stimulates MUS81-EME1 endonuclease leading to mitotic DNA synthesis (PubMed:28575661). Required for efficient DNA repair, including repair of inter-strand cross-links (PubMed:23715498). Stimulates DNA decatenation mediated by TOP2A. Prevents sister chromatid exchange and homologous recombination. A core helicase fragment (residues 11-609) binds preferentially to splayed duplex, looped and ssDNA (PubMed:28100692)