Unconventional prefoldin RPB5 interactor 1 (Protein NNX3) (Protein phosphatase 1 regulatory subunit 19) (RNA polymerase II subunit 5-mediating protein) (RPB5-mediating protein)
1_MEAPT 6_ VETPP 11_ DPSPP 16_ SAPAP 21_ ALVPL 26_ RAPDV 31_ ARLRE 36_ EQEKV 41_ VTNCQ 46_ ERIQH 51_ WKKVD 56_ NDYNA 61_ LRERL 66_ STLPD 71_ KLSYN 76_ IMVPF 81_ GPFAF 86_ MPGKL 91_ VHTNE 96_ VTVLL 101_ GDNWF 106_ AKCSA 111_ KQAVG 116_ LVEHR 121_ KEHVR 126_ KTIDD 131_ LKKVM 136_ KNFES 141_ RVEFT 146_ EDLQK 151_ MSDAA 156_ GDIVD 161_ IREEI 166_ KCDFE 171_ FKAKH 176_ RIAHK 181_ PHSKP 186_ KTSDI 191_ FEADI 196_ ANDVK 201_ SKDLL 206_ ADKEL 211_ WARLE 216_ ELERQ 221_ EELLG 226_ ELDSK 231_ PDTVI 236_ ANGED 241_ TTSSE 246_ EEKED 251_ RNTNV 256_ NAMHQ 261_ VTDSH 266_ TPCHK 271_ DVASS 276_ EPFSG 281_ QVNSQ 286_ LNCSV 291_ NGSSS 296_ YHSDD 301_ DDDDD 306_ DDDDD 311_ DNIDD 316_ DDGDN 321_ DHEAL 326_ GVGDN 331_ SIPTI 336_ YFSHT 341_ VEPKR 346_ VRINT 351_ GKNTT 356_ LKFSE 361_ KKEEA 366_ KRKRK 371_ NSTGS 376_ GHSAQ 381_ ELPTI 386_ RTPAD 391_ IYRAF 396_ VDVVN 401_ GEYVP 406_ RKSIL 411_ KSRSR 416_ ENSVC 421_ SDTSE 426_ SSAAE 431_ FDDRR 436_ GVLRS 441_ ISCEE 446_ ATCSD 451_ TSESI 456_ LEEEP 461_ QENQK 466_ KLLPL 471_ SVTPE 476_ AFSGT 481_ VIEKE 486_ FVSPS 491_ LTPPP 496_ AIAHP 501_ ALPTI 506_ PERKE 511_ VLLEA 516_ SEETG 521_ KRVSK 526_FKAAR
1: Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein
2: Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination