Ubiquitin carboxyl-terminal hydrolase 1 (EC 3.4.19.12) (Deubiquitinating enzyme 1) (hUBP) (Ubiquitin thioesterase 1) (Ubiquitin-specific-processing protease 1) [Cleaved into: Ubiquitin carboxyl-terminal hydrolase 1, N-terminal fragment]
1_MPGVI 6_ PSESN 11_ GLSRG 16_ SPSKK 21_ NRLSL 26_ KFFQK 31_ KETKR 36_ ALDFT 41_ DSQEN 46_ EEKAS 51_ EYRAS 56_ EIDQV 61_ VPAAQ 66_ SSPIN 71_ CEKRE 76_ NLLPF 81_ VGLNN 86_ LGNTC 91_ YLNSI 96_ LQVLY 101_ FCPGF 106_ KSGVK 111_ HLFNI 116_ ISRKK 121_ EALKD 126_ EANQK 131_ DKGNC 136_ KEDSL 141_ ASYEL 146_ ICSLQ 151_ SLIIS 156_ VEQLQ 161_ ASFLL 166_ NPEKY 171_ TDELA 176_ TQPRR 181_ LLNTL 186_ RELNP 191_ MYEGY 196_ LQHDA 201_ QEVLQ 206_ CILGN 211_ IQETC 216_ QLLKK 221_ EEVKN 226_ VAELP 231_ TKVEE 236_ IPHPK 241_ EEMNG 246_ INSIE 251_ MDSMR 256_ HSEDF 261_ KEKLP 266_ KGNGK 271_ RKSDT 276_ EFGNM 281_ KKKVK 286_ LSKEH 291_ QSLEE 296_ NQRQT 301_ RSKRK 306_ ATSDT 311_ LESPP 316_ KIIPK 321_ YISEN 326_ ESPRP 331_ SQKKS 336_ RVKIN 341_ WLKSA 346_ TKQPS 351_ ILSKF 356_ CSLGK 361_ ITTNQ 366_ GVKGQ 371_ SKENE 376_ CDPEE 381_ DLGKC 386_ ESDNT 391_ TNGCG 396_ LESPG 401_ NTVTP 406_ VNVNE 411_ VKPIN 416_ KGEEQ 421_ IGFEL 426_ VEKLF 431_ QGQLV 436_ LRTRC 441_ LECES 446_ LTERR 451_ EDFQD 456_ ISVPV 461_ QEDEL 466_ SKVEE 471_ SSEIS 476_ PEPKT 481_ EMKTL 486_ RWAIS 491_ QFASV 496_ ERIVG 501_ EDKYF 506_ CENCH 511_ HYTEA 516_ ERSLL 521_ FDKMP 526_ EVITI 531_ HLKCF 536_ AASGL 541_ EFDCY 546_ GGGLS 551_ KINTP 556_ LLTPL 561_ KLSLE 566_ EWSTK 571_ PTNDS 576_ YGLFA 581_ VVMHS 586_ GITIS 591_ SGHYT 596_ ASVKV 601_ TDLNS 606_ LELDK 611_ GNFVV 616_ DQMCE 621_ IGKPE 626_ PLNEE 631_ EARGV 636_ VENYN 641_ DEEVS 646_ IRVGG 651_ NTQPS 656_ KVLNK 661_ KNVEA 666_ IGLLG 671_ GQKSK 676_ ADYEL 681_ YNKAS 686_ NPDKV 691_ ASTAF 696_ AENRN 701_ SETSD 706_ TTGTH 711_ ESDRN 716_ KESSD 721_ QTGIN 726_ ISGFE 731_ NKISY 736_ VVQSL 741_ KEYEG 746_ KWLLF 751_ DDSEV 756_ KVTEE 761_ KDFLN 766_ SLSPS 771_ TSPTS 776_TPYLL
1: Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2 (PubMed:15694335). Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA (PubMed:16531995, PubMed:20147293). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:18082604, PubMed:26388029)