Retinal dehydrogenase 2 (RALDH 2) (RalDH2) (EC 1.2.1.36) (Aldehyde dehydrogenase family 1 member A2) (Retinaldehyde-specific dehydrogenase type 2) (RALDH(II))
1_MTSSK 6_ IEMPG 11_ EVKAD 16_ PAALM 21_ ASLHL 26_ LPSPT 31_ PNLEI 36_ KYTKI 41_ FINNE 46_ WQNSE 51_ SGRVF 56_ PVYNP 61_ ATGEQ 66_ VCEVQ 71_ EADKA 76_ DIDKA 81_ VQAAR 86_ LAFSL 91_ GSVWR 96_ RMDAS 101_ ERGRL 106_ LDKLA 111_ DLVER 116_ DRAVL 121_ ATMES 126_ LNGGK 131_ PFLQA 136_ FYVDL 141_ QGVIK 146_ TFRYY 151_ AGWAD 156_ KIHGM 161_ TIPVD 166_ GDYFT 171_ FTRHE 176_ PIGVC 181_ GQIIP 186_ WNFPL 191_ LMFAW 196_ KIAPA 201_ LCCGN 206_ TVVIK 211_ PAEQT 216_ PLSAL 221_ YMGAL 226_ IKEAG 231_ FPPGV 236_ INILP 241_ GYGPT 246_ AGAAI 251_ ASHIG 256_ IDKIA 261_ FTGST 266_ EVGKL 271_ IQEAA 276_ GRSNL 281_ KRVTL 286_ ELGGK 291_ SPNII 296_ FADAD 301_ LDYAV 306_ EQAHQ 311_ GVFFN 316_ QGQCC 321_ TAGSR 326_ IFVEE 331_ SIYEE 336_ FVRRS 341_ VERAK 346_ RRVVG 351_ SPFDP 356_ TTEQG 361_ PQIDK 366_ KQYNK 371_ ILELI 376_ QSGVA 381_ EGAKL 386_ ECGGK 391_ GLGRK 396_ GFFIE 401_ PTVFS 406_ NVTDD 411_ MRIAK 416_ EEIFG 421_ PVQEI 426_ LRFKT 431_ MDEVI 436_ ERANN 441_ SDFGL 446_ VAAVF 451_ TNDIN 456_ KALTV 461_ SSAMQ 466_ AGTVW 471_ INCYN 476_ ALNAQ 481_ SPFGG 486_ FKMSG 491_ NGREM 496_ GEFGL 501_ REYSE 506_ VKTVT 511_VKIPQ
1: Catalyzes the NAD-dependent oxidation of aldehyde substrates, such as all-trans-retinal and all-trans-13,14-dihydroretinal, to their corresponding carboxylic acids, all-trans-retinoate and all-trans-13,14-dihydroretinoate, respectively (PubMed:29240402, PubMed:33565183). Retinoate signaling is critical for the transcriptional control of many genes, for instance it is crucial for initiation of meiosis in both male and female (Probable) (PubMed:33565183). Recognizes retinal as substrate, both in its free form and when bound to cellular retinol-binding protein (By similarity). Can metabolize octanal and decanal, but has only very low activity with benzaldehyde, acetaldehyde and propanal (By similarity). Displays complete lack of activity with citral (By similarity)