Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase)
1_MAFAN 6_ FRRIL 11_ RLSTF 16_ EKRKS 21_ REYEH 26_ VRRDL 31_ DPNEV 36_ WEIVG 41_ ELGDG 46_ AFGKV 51_ YKAKN 56_ KETGA 61_ LAAAK 66_ VIETK 71_ SEEEL 76_ EDYIV 81_ EIEIL 86_ ATCDH 91_ PYIVK 96_ LLGAY 101_ YHDGK 106_ LWIMI 111_ EFCPG 116_ GAVDA 121_ IMLEL 126_ DRGLT 131_ EPQIQ 136_ VVCRQ 141_ MLEAL 146_ NFLHS 151_ KRIIH 156_ RDLKA 161_ GNVLM 166_ TLEGD 171_ IRLAD 176_ FGVSA 181_ KNLKT 186_ LQKRD 191_ SFIGT 196_ PYWMA 201_ PEVVM 206_ CETMK 211_ DTPYD 216_ YKADI 221_ WSLGI 226_ TLIEM 231_ AQIEP 236_ PHHEL 241_ NPMRV 246_ LLKIA 251_ KSDPP 256_ TLLTP 261_ SKWSV 266_ EFRDF 271_ LKIAL 276_ DKNPE 281_ TRPSA 286_ AQLLE 291_ HPFVS 296_ SITSN 301_ KALRE 306_ LVAEA 311_ KAEVM 316_ EEIED 321_ GRDEG 326_ EEEDA 331_ VDAAS 336_ TLENH 341_ TQNSS 346_ EVSPP 351_ SLNAD 356_ KPLEE 361_ SPSTP 366_ LAPSQ 371_ SQDSV 376_ NEPCS 381_ QPSGD 386_ RSLQT 391_ TSPPV 396_ VAPGN 401_ ENGLA 406_ VPVPL 411_ RKSRP 416_ VSMDA 421_ RIQVA 426_ QEKQV 431_ AEQGG 436_ DLSPA 441_ ANRSQ 446_ KASQS 451_ RPNSS 456_ ALETL 461_ GGEKL 466_ ANGSL 471_ EPPAQ 476_ AAPGP 481_ SKRDS 486_ DCSSL 491_ CTSES 496_ MDYGT 501_ NLSTD 506_ LSLNK 511_ EMGSL 516_ SIKDP 521_ KLYKK 526_ TLKRT 531_ RKFVV 536_ DGVEV 541_ SITTS 546_ KIISE 551_ DEKKD 556_ EEMRF 561_ LRRQE 566_ LRELR 571_ LLQKE 576_ EHRNQ 581_ TQLSN 586_ KHELQ 591_ LEQMH 596_ KRFEQ 601_ EINAK 606_ KKFFD 611_ TELEN 616_ LERQQ 621_ KQQVE 626_ KMEQD 631_ HAVRR 636_ REEAR 641_ RIRLE 646_ QDRDY 651_ TRFQE 656_ QLKLM 661_ KKEVK 666_ NEVEK 671_ LPRQQ 676_ RKESM 681_ KQKME 686_ EHTQK 691_ KQLLD 696_ RDFVA 701_ KQKED 706_ LELAM 711_ KRLTT 716_ DNRRE 721_ ICDKE 726_ RECLM 731_ KKQEL 736_ LRDRE 741_ AALWE 746_ MEEHQ 751_ LQERH 756_ QLVKQ 761_ QLKDQ 766_ YFLQR 771_ HELLR 776_ KHEKE 781_ REQMQ 786_ RYNQR 791_ MIEQL 796_ KVRQQ 801_ QEKAR 806_ LPKIQ 811_ RSEGK 816_ TRMAM 821_ YKKSL 826_ HINGG 831_ GSAAE 836_ QREKI 841_ KQFSQ 846_ QEEKR 851_ QKSER 856_ LQQQQ 861_ KHENQ 866_ MRDML 871_ AQCES 876_ NMSEL 881_ QQLQN 886_ EKCHL 891_ LVEHE 896_ TQKLK 901_ ALDES 906_ HNQNL 911_ KEWRD 916_ KLRPR 921_ KKALE 926_ EDLNQ 931_ KKREQ 936_ EMFFK 941_ LSEEA 946_ ECPNP 951_ STPSK 956_ AAKFF 961_PYSSA
1: Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo