Actin-like protein 6B (53 kDa BRG1-associated factor B) (Actin-related protein Baf53b) (ArpNalpha) (BRG1-associated factor 53B) (BAF53B)
1_MSGGV 6_ YGGDE 11_ VGALV 16_ FDIGS 21_ FSVRA 26_ GYAGE 31_ DCPKA 36_ DFPTT 41_ VGLLA 46_ AEEGG 51_ GLELE 56_ GDKEK 61_ KGKIF 66_ HIDTN 71_ ALHVP 76_ RDGAE 81_ VMSPL 86_ KNGMI 91_ EDWEC 96_ FRAIL 101_ DHTYS 106_ KHVKS 111_ EPNLH 116_ PVLMS 121_ EAPWN 126_ TRAKR 131_ EKLTE 136_ LMFEQ 141_ YNIPA 146_ FFLCK 151_ TAVLT 156_ AFANG 161_ RSTGL 166_ VLDSG 171_ ATHTT 176_ AIPVH 181_ DGYVL 186_ QQGIV 191_ KSPLA 196_ GDFIS 201_ MQCRE 206_ LFQEM 211_ AIDII 216_ PPYMI 221_ AAKEP 226_ VREGA 231_ PPNWK 236_ KKEKL 241_ PQVSK 246_ SWHNY 251_ MCNEV 256_ IQDFQ 261_ ASVLQ 266_ VSDSP 271_ YDEQV 276_ AAQMP 281_ TVHYE 286_ MPNGY 291_ NTDYG 296_ AERLR 301_ IPEGL 306_ FDPSN 311_ VKGLS 316_ GNTML 321_ GVGHV 326_ VTTSI 331_ GMCDI 336_ DIRPG 341_ LYGSV 346_ IVTGG 351_ NTLLQ 356_ GFTDR 361_ LNREL 366_ SQKTP 371_ PSMRL 376_ KLIAS 381_ NSTME 386_ RKFSP 391_ WIGGS 396_ ILASL 401_ GTFQQ 406_ MWISK 411_ QEYEE 416_ GGKQC 421_VERKC
1: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex), as such plays a role in remodeling mononucleosomes in an ATP-dependent fashion, and is required for postmitotic neural development and dendritic outgrowth. During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. ACTL6B/BAF53B is not essential for assembly of the nBAF complex but is required for targeting the complex and CREST to the promoter of genes essential for dendritic growth (By similarity). Essential for neuronal maturation and dendrite development (PubMed:31031012)