Tubulin polymerization-promoting protein (TPPP) (EC 3.6.5.-) (25 kDa brain-specific protein) (TPPP/p25) (p24) (p25-alpha)
1_MADKA 6_ KPAKA 11_ ANRTP 16_ PKSPG 21_ DPSKD 26_ RAAKR 31_ LSLES 36_ EGAGE 41_ GAAAS 46_ PELSA 51_ LEEAF 56_ RRFAV 61_ HGDAR 66_ ATGRE 71_ MHGKN 76_ WSKLC 81_ KDCQV 86_ IDGRN 91_ VTVTD 96_ VDIVF 101_ SKIKG 106_ KSCRT 111_ ITFEQ 116_ FQEAL 121_ EELAK 126_ KRFKD 131_ KSSEE 136_ AVREV 141_ HRLIE 146_ GKAPI 151_ ISGVT 156_ KAISS 161_ PTVSR 166_ LTDTT 171_ KFTGS 176_ HKERF 181_ DPSGK 186_ GKGKA 191_ GRVDL 196_ VDESG 201_ YVSGY 206_ KHAGT 211_YDQKV
1: Regulator of microtubule dynamics that plays a key role in myelination by promoting elongation of the myelin sheath (PubMed:31522887). Acts as a microtubule nucleation factor in oligodendrocytes: specifically localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, and promotes microtubule nucleation, an important step for elongation of the myelin sheath (PubMed:31522887, PubMed:33831707). Required for both uniform polarized growth of distal microtubules as well as directing the branching of proximal processes (PubMed:31522887). Shows magnesium-dependent GTPase activity; the role of the GTPase activity is unclear (PubMed:21316364, PubMed:21995432). In addition to microtubule nucleation activity, also involved in microtubule bundling and stabilization of existing microtubules, thereby maintaining the integrity of the microtubule network (PubMed:17105200, PubMed:17693641, PubMed:18028908, PubMed:26289831). Regulates microtubule dynamics by promoting tubulin acetylation: acts by inhibiting the tubulin deacetylase activity of HDAC6 (PubMed:20308065, PubMed:23093407). Also regulates cell migration: phosphorylation by ROCK1 inhibits interaction with HDAC6, resulting in decreased acetylation of tubulin and increased cell motility (PubMed:23093407). Plays a role in cell proliferation by regulating the G1/S-phase transition (PubMed:23355470). Involved in astral microtubule organization and mitotic spindle orientation during early stage of mitosis; this process is regulated by phosphorylation by LIMK2 (PubMed:22328514)