Slit homolog 2 protein (Slit-2) [Cleaved into: Slit homolog 2 protein N-product; Slit homolog 2 protein C-product]
1_MRGVG 6_ WQMLS 11_ LSLGL 16_ VLAIL 21_ NKVAP 26_ QACPA 31_ QCSCS 36_ GSTVD 41_ CHGLA 46_ LRSVP 51_ RNIPR 56_ NTERL 61_ DLNGN 66_ NITRI 71_ TKTDF 76_ AGLRH 81_ LRVLQ 86_ LMENK 91_ ISTIE 96_ RGAFQ 101_ DLKEL 106_ ERLRL 111_ NRNHL 116_ QLFPE 121_ LLFLG 126_ TAKLY 131_ RLDLS 136_ ENQIQ 141_ AIPRK 146_ AFRGA 151_ VDIKN 156_ LQLDY 161_ NQISC 166_ IEDGA 171_ FRALR 176_ DLEVL 181_ TLNNN 186_ NITRL 191_ SVASF 196_ NHMPK 201_ LRTFR 206_ LHSNN 211_ LYCDC 216_ HLAWL 221_ SDWLR 226_ QRPRV 231_ GLYTQ 236_ CMGPS 241_ HLRGH 246_ NVAEV 251_ QKREF 256_ VCSGH 261_ QSFMA 266_ PSCSV 271_ LHCPA 276_ ACTCS 281_ NNIVD 286_ CRGKG 291_ LTEIP 296_ TNLPE 301_ TITEI 306_ RLEQN 311_ TIKVI 316_ PPGAF 321_ SPYKK 326_ LRRID 331_ LSNNQ 336_ ISELA 341_ PDAFQ 346_ GLRSL 351_ NSLVL 356_ YGNKI 361_ TELPK 366_ SLFEG 371_ LFSLQ 376_ LLLLN 381_ ANKIN 386_ CLRVD 391_ AFQDL 396_ HNLNL 401_ LSLYD 406_ NKLQT 411_ IAKGT 416_ FSPLR 421_ AIQTM 426_ HLAQN 431_ PFICD 436_ CHLKW 441_ LADYL 446_ HTNPI 451_ ETSGA 456_ RCTSP 461_ RRLAN 466_ KRIGQ 471_ IKSKK 476_ FRCSA 481_ KEQYF 486_ IPGTE 491_ DYRSK 496_ LSGDC 501_ FADLA 506_ CPEKC 511_ RCEGT 516_ TVDCS 521_ NQKLN 526_ KIPEH 531_ IPQYT 536_ AELRL 541_ NNNEF 546_ TVLEA 551_ TGIFK 556_ KLPQL 561_ RKINF 566_ SNNKI 571_ TDIEE 576_ GAFEG 581_ ASGVN 586_ EILLT 591_ SNRLE 596_ NVQHK 601_ MFKGL 606_ ESLKT 611_ LMLRS 616_ NRITC 621_ VGNDS 626_ FIGLS 631_ SVRLL 636_ SLYDN 641_ QITTV 646_ APGAF 651_ DTLHS 656_ LSTLN 661_ LLANP 666_ FNCNC 671_ YLAWL 676_ GEWLR 681_ KKRIV 686_ TGNPR 691_ CQKPY 696_ FLKEI 701_ PIQDV 706_ AIQDF 711_ TCDDG 716_ NDDNS 721_ CSPLS 726_ RCPTE 731_ CTCLD 736_ TVVRC 741_ SNKGL 746_ KVLPK 751_ GIPRD 756_ VTELY 761_ LDGNQ 766_ FTLVP 771_ KELSN 776_ YKHLT 781_ LIDLS 786_ NNRIS 791_ TLSNQ 796_ SFSNM 801_ TQLLT 806_ LILSY 811_ NRLRC 816_ IPPRT 821_ FDGLK 826_ SLRLL 831_ SLHGN 836_ DISVV 841_ PEGAF 846_ NDLSA 851_ LSHLA 856_ IGANP 861_ LYCDC 866_ NMQWL 871_ SDWVK 876_ SEYKE 881_ PGIAR 886_ CAGPG 891_ EMADK 896_ LLLTT 901_ PSKKF 906_ TCQGP 911_ VDVNI 916_ LAKCN 921_ PCLSN 926_ PCKND 931_ GTCNS 936_ DPVDF 941_ YRCTC 946_ PYGFK 951_ GQDCD 956_ VPIHA 961_ CISNP 966_ CKHGG 971_ TCHLK 976_ EGEED 981_ GFWCI 986_ CADGF 991_ EGENC 996_ EVNVD 1001_ DCEDN 1006_ DCENN 1011_ STCVD 1016_ GINNY 1021_ TCLCP 1026_ PEYTG 1031_ ELCEE 1036_ KLDFC 1041_ AQDLN 1046_ PCQHD 1051_ SKCIL 1056_ TPKGF 1061_ KCDCT 1066_ PGYVG 1071_ EHCDI 1076_ DFDDC 1081_ QDNKC 1086_ KNGAH 1091_ CTDAV 1096_ NGYTC 1101_ ICPEG 1106_ YSGLF 1111_ CEFSP 1116_ PMVLP 1121_ RTSPC 1126_ DNFDC 1131_ QNGAQ 1136_ CIVRI 1141_ NEPIC 1146_ QCLPG 1151_ YQGEK 1156_ CEKLV 1161_ SVNFI 1166_ NKESY 1171_ LQIPS 1176_ AKVRP 1181_ QTNIT 1186_ LQIAT 1191_ DEDSG 1196_ ILLYK 1201_ GDKDH 1206_ IAVEL 1211_ YRGRV 1216_ RASYD 1221_ TGSHP 1226_ ASAIY 1231_ SVETI 1236_ NDGNF 1241_ HIVEL 1246_ LALDQ 1251_ SLSLS 1256_ VDGGN 1261_ PKIIT 1266_ NLSKQ 1271_ STLNF 1276_ DSPLY 1281_ VGGMP 1286_ GKSNV 1291_ ASLRQ 1296_ APGQN 1301_ GTSFH 1306_ GCIRN 1311_ LYINS 1316_ ELQDF 1321_ QKVPM 1326_ QTGIL 1331_ PGCEP 1336_ CHKKV 1341_ CAHGT 1346_ CQPSS 1351_ QAGFT 1356_ CECQE 1361_ GWMGP 1366_ LCDQR 1371_ TNDPC 1376_ LGNKC 1381_ VHGTC 1386_ LPINA 1391_ FSYSC 1396_ KCLEG 1401_ HGGVL 1406_ CDEEE 1411_ DLFNP 1416_ CQAIK 1421_ CKHGK 1426_ CRLSG 1431_ LGQPY 1436_ CECSS 1441_ GYTGD 1446_ SCDRE 1451_ ISCRG 1456_ ERIRD 1461_ YYQKQ 1466_ QGYAA 1471_ CQTTK 1476_ KVSRL 1481_ ECRGG 1486_ CAGGQ 1491_ CCGPL 1496_ RSKRR 1501_ KYSFE 1506_ CTDGS 1511_ SFVDE 1516_ VEKVV 1521_KCGCT
1: Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal cord development may play a role in guiding commissural axons once they reached the floor plate by modulating the response to netrin. In vitro, silences the attractive effect of NTN1 but not its growth-stimulatory effect and silencing requires the formation of a ROBO1-DCC complex. May be implicated in spinal cord midline post-crossing axon repulsion. In vitro, only commissural axons that crossed the midline responded to SLIT2. In the developing visual system appears to function as repellent for retinal ganglion axons by providing a repulsion that directs these axons along their appropriate paths prior to, and after passage through, the optic chiasm. In vitro, collapses and repels retinal ganglion cell growth cones. Seems to play a role in branching and arborization of CNS sensory axons, and in neuronal cell migration. In vitro, Slit homolog 2 protein N-product, but not Slit homolog 2 protein C-product, repels olfactory bulb (OB) but not dorsal root ganglia (DRG) axons, induces OB growth cones collapse and induces branching of DRG axons. Seems to be involved in regulating leukocyte migration