Ubiquitin-like protein ATG12 (Autophagy-related protein 12) (APG12-like)
1_MAEEP 6_ QSVLQ 11_ LPTSI 16_ AAGGE 21_ GLTDV 26_ SPETT 31_ TPEPP 36_ SSAAV 41_ SPGTE 46_ EPAGD 51_ TKKKI 56_ DILLK 61_ AVGDT 66_ PIMKT 71_ KKWAV 76_ ERTRT 81_ IQGLI 86_ DFIKK 91_ FLKLV 96_ ASEQL 101_ FIYVN 106_ QSFAP 111_ SPDQE 116_ VGTLY 121_ ECFGS 126_ DGKLV 131_LHYCK
1: Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. As part of the ATG8 conjugation system with ATG5 and ATG16L1, required for recruitment of LRRK2 to stressed lysosomes and induction of LRRK2 kinase activity in response to lysosomal stress (By similarity)
2: (Microbial infection) May act as a proviral factor. In association with ATG5, negatively regulates the innate antiviral immune response by impairing the type I IFN production pathway upon vesicular stomatitis virus (VSV) infection (PubMed:17709747). Required for the translation of incoming hepatitis C virus (HCV) RNA and, thereby, for the initiation of HCV replication, but not required once infection is established (PubMed:19666601)