Mitochondrial import receptor subunit TOM70 (Mitochondrial precursor proteins import receptor) (Translocase of outer membrane 70 kDa subunit) (Translocase of outer mitochondrial membrane protein 70)
1_MAASK 6_ PVEAA 11_ VVAAA 16_ VPSSG 21_ SGVGG 26_ GGTAG 31_ PGTGG 36_ LPRWQ 41_ LALAV 46_ GAPLL 51_ LGAGA 56_ IYLWS 61_ RQQRR 66_ REARG 71_ RGDAS 76_ GLKRN 81_ SERKT 86_ PEGRA 91_ SPAPG 96_ SGHPE 101_ GPGAH 106_ LDMNS 111_ LDRAQ 116_ AAKNK 121_ GNKYF 126_ KAGKY 131_ EQAIQ 136_ CYTEA 141_ ISLCP 146_ TEKNV 151_ DLSTF 156_ YQNRA 161_ AAFEQ 166_ LQKWK 171_ EVAQD 176_ CTKAV 181_ ELNPK 186_ YVKAL 191_ FRRAK 196_ AHEKL 201_ DNKKE 206_ CLEDV 211_ TAVCI 216_ LEGFQ 221_ NQQSM 226_ LLADK 231_ VLKLL 236_ GKEKA 241_ KEKYK 246_ NREPL 251_ MPSPQ 256_ FIKSY 261_ FSSFT 266_ DDIIS 271_ QPMLK 276_ GEKSD 281_ EDKDK 286_ EGEAL 291_ EVKEN 296_ SGYLK 301_ AKQYM 306_ EEENY 311_ DKIIS 316_ ECSKE 321_ IDAEG 326_ KYMAE 331_ ALLLR 336_ ATFYL 341_ LIGNA 346_ NAAKP 351_ DLDKV 356_ ISLKE 361_ ANVKL 366_ RANAL 371_ IKRGS 376_ MYMQQ 381_ QQPLL 386_ STQDF 391_ NMAAD 396_ IDPQN 401_ ADVYH 406_ HRGQL 411_ KILLD 416_ QVEEA 421_ VADFD 426_ ECIRL 431_ RPESA 436_ LAQAQ 441_ KCFAL 446_ YRQAY 451_ TGNNS 456_ SQIQA 461_ AMKGF 466_ EEVIK 471_ KFPRC 476_ AEGYA 481_ LYAQA 486_ LTDQQ 491_ QFGKA 496_ DEMYD 501_ KCIDL 506_ EPDNA 511_ TTYVH 516_ KGLLQ 521_ LQWKQ 526_ DLDRG 531_ LELIS 536_ KAIEI 541_ DNKCD 546_ FAYET 551_ MGTIE 556_ VQRGN 561_ MEKAI 566_ DMFNK 571_ AINLA 576_ KSEME 581_ MAHLY 586_ SLCDA 591_ AHAQT 596_ EVAKK 601_YGLKP
1: Acts as a receptor of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) (PubMed:12526792). Recognizes and mediates the translocation of mitochondrial preproteins from the cytosol into the mitochondria in a chaperone dependent manner (PubMed:12526792, PubMed:35025629). Mediates TBK1 and IRF3 activation induced by MAVS in response to Sendai virus infection and promotes host antiviral responses during virus infection (PubMed:20628368, PubMed:25609812, PubMed:32728199). Upon Sendai virus infection, recruits HSP90AA1:IRF3:BAX in mitochondrion and the complex induces apoptosis (PubMed:25609812)