Pleckstrin homology domain-containing family G member 5 (PH domain-containing family G member 5) (Guanine nucleotide exchange factor 720) (GEF720)
1_MHYDG 6_ HVRFD 11_ LPPQG 16_ SVLAR 21_ NVSTR 26_ SCPPR 31_ TSPAV 36_ DLEEE 41_ EEESS 46_ VDGKG 51_ DRKST 56_ GLKLS 61_ KKKAR 66_ RRHTD 71_ DPSKE 76_ CFTLK 81_ FDLNV 86_ DIETE 91_ IVPAM 96_ KKKSL 101_ GEVLL 106_ PVFER 111_ KGIAL 116_ GKVDI 121_ YLDQS 126_ NTPLS 131_ LTFEA 136_ YRFGG 141_ HYLRV 146_ KAPAK 151_ PGDEG 156_ KVEQG 161_ MKDSK 166_ SLSLP 171_ ILRPA 176_ GTGPP 181_ ALERV 186_ DAQSR 191_ RESLD 196_ ILAPG 201_ RRRKN 206_ MSEFL 211_ GEASI 216_ PGQEP 221_ PTPSS 226_ CSLPS 231_ GSSGS 236_ TNTGD 241_ SWKNR 246_ AASRF 251_ SGFFS 256_ SGPST 261_ SAFGR 266_ EVDKM 271_ EQLEG 276_ KLHTY 281_ SLFGL 286_ PRLPR 291_ GLRFD 296_ HDSWE 301_ EEYDE 306_ DEDED 311_ NACLR 316_ LEDSW 321_ RELID 326_ GHEKL 331_ TRRQC 336_ HQQEA 341_ VWELL 346_ HTEAS 351_ YIRKL 356_ RVIIN 361_ LFLCC 366_ LLNLQ 371_ ESGLL 376_ CEVEA 381_ ERLFS 386_ NIPEI 391_ AQLHR 396_ RLWAS 401_ VMAPV 406_ LEKAR 411_ RTRAL 416_ LQPGD 421_ FLKGF 426_ KMFGS 431_ LFKPY 436_ IRYCM 441_ EEEGC 446_ MEYMR 451_ GLLRD 456_ NDLFR 461_ AYITW 466_ AEKHP 471_ QCQRL 476_ KLSDM 481_ LAKPH 486_ QRLTK 491_ YPLLL 496_ KSVLR 501_ KTEEP 506_ RAKEA 511_ VVAMI 516_ GSVER 521_ FIHHV 526_ NACMR 531_ QRQER 536_ QRLAA 541_ VVSRI 546_ DAYEV 551_ VESSS 556_ DEVDK 561_ LLKEF 566_ LHLDL 571_ TAPIP 576_ GASPE 581_ ETRQL 586_ LLEGS 591_ LRMKE 596_ GKDSK 601_ MDVYC 606_ FLFTD 611_ LLLVT 616_ KAVKK 621_ AERTR 626_ VIRPP 631_ LLVDK 636_ IVCRE 641_ LRDPG 646_ SFLLI 651_ YLNEF 656_ HSAVG 661_ AYTFQ 666_ ASGQA 671_ LCRGW 676_ VDTIY 681_ NAQNQ 686_ LQQLR 691_ AQEPP 696_ GSQQP 701_ LQSLE 706_ EEEDE 711_ QEEEE 716_ EEEEE 721_ EEEGE 726_ DSGTS 731_ AASSP 736_ TIMRK 741_ SSGSP 746_ DSQHC 751_ ASDGS 756_ TETLA 761_ MVVVE 766_ PGDTL 771_ SSPEF 776_ DSGPF 781_ SSQSD 786_ ETSLS 791_ TTASS 796_ ATPTS 801_ ELLPL 806_ GPVDG 811_ RSCSM 816_ DSAYG 821_ TLSPT 826_ SLQDF 831_ VAPGP 836_ MAELV 841_ PRAPE 846_ SPRVP 851_ SPPPS 856_ PRLRR 861_ RTPVQ 866_ LLSCP 871_ PHLLK 876_ SKSEA 881_ SLLQL 886_ LAGAG 891_ THGTP 896_ SAPSR 901_ SLSEL 906_ CLAVP 911_ APGIR 916_ TQGSP 921_ QEAGP 926_ SWDCR 931_ GAPSP 936_ GSGPG 941_ LVGCL 946_ AGEPA 951_ GSHRK 956_ RCGDL 961_ PSGAS 966_ PRVQP 971_ EPPPG 976_ VSAQH 981_ RKLTL 986_ AQLYR 991_ IRTTL 996_ LLNST 1001_LTASE
1: Functions as a guanine exchange factor (GEF) for RAB26 and thus regulates autophagy of synaptic vesicles in axon terminal of motoneurons (By similarity). Involved in the control of neuronal cell differentiation (PubMed:11704860). Plays a role in angiogenesis through regulation of endothelial cells chemotaxis. Also affects the migration, adhesion, and matrix/bone degradation in macrophages and osteoclasts (PubMed:23777631)