Importin-13 (Imp13) (Karyopherin-13) (Kap13) (Ran-binding protein 13) (RanBP13)
1_MERRE 6_ EQPGA 11_ AGAGA 16_ APALD 21_ FTVEN 26_ VEKAL 31_ HQLYY 36_ DPNIE 41_ NKNLA 46_ QKWLM 51_ QAQVS 56_ PQAWH 61_ FSWQL 66_ LQPDK 71_ VPEIQ 76_ YFGAS 81_ ALHIK 86_ ISRYW 91_ SDIPT 96_ DQYES 101_ LKAQL 106_ FTQIT 111_ RFASG 116_ SKIVL 121_ TRLCV 126_ ALASL 131_ ALSMM 136_ PDAWP 141_ CAVAD 146_ MVRLF 151_ QAEDS 156_ PVDGQ 161_ GRCLA 166_ LLELL 171_ TVLPE 176_ EFQTS 181_ RLPQY 186_ RKGLV 191_ RTSLA 196_ VECGA 201_ VFPLL 206_ EQLLQ 211_ QPSSP 216_ SCVRQ 221_ KVLKC 226_ FSSWV 231_ QLEVP 236_ LQDCE 241_ ALIQA 246_ AFAAL 251_ QDSEL 256_ FDSSV 261_ EAIVN 266_ AISQP 271_ DAQRY 276_ VNTLL 281_ KLIPL 286_ VLGLQ 291_ EQLRQ 296_ AVQNG 301_ DMETS 306_ HGICR 311_ IAVAL 316_ GENHS 321_ RALLD 326_ QVEHW 331_ QSFLA 336_ LVNMI 341_ MFCTG 346_ IPGHY 351_ PVNET 356_ TSSLT 361_ LTFWY 366_ TLQDD 371_ ILSFE 376_ AEKQA 381_ VYQQV 386_ YRPVY 391_ FQLVD 396_ VLLHK 401_ AQFPS 406_ DEEYG 411_ FWSSD 416_ EKEQF 421_ RIYRV 426_ DISDT 431_ LMYVY 436_ EMLGA 441_ ELLSN 446_ LYDKL 451_ GRLLT 456_ SSEEP 461_ YSWQH 466_ TEALL 471_ YGFQS 476_ IAETI 481_ DVNYS 486_ DVVPG 491_ LIGLI 496_ PRISI 501_ SNVQL 506_ ADTVM 511_ FTIGA 516_ LSEWL 521_ ADHPV 526_ MINSV 531_ LPLVL 536_ HALGN 541_ PELSV 546_ SSVST 551_ LKKIC 556_ RECKY 561_ DLPPY 566_ AANIV 571_ AVSQD 576_ VLMKQ 581_ IHKTS 586_ QCMWL 591_ MQALG 596_ FLLSA 601_ LQVEE 606_ ILKNL 611_ HSLIS 616_ PYIQQ 621_ LEKLA 626_ EEIPN 631_ PSNKL 636_ AIVHI 641_ LGLLS 646_ NLFTT 651_ LDISH 656_ HEDDH 661_ EGPEL 666_ RKLPV 671_ PQGPN 676_ PVVVV 681_ LQQVF 686_ QLIQK 691_ VLSKW 696_ LNDAQ 701_ VVEAV 706_ CAIFE 711_ KSVKT 716_ LLDDF 721_ APMVP 726_ QLCEM 731_ LGRMY 736_ STIPQ 741_ ASALD 746_ LTRQL 751_ VHIFA 756_ HEPAH 761_ FPPIE 766_ ALFLL 771_ VTSVT 776_ LTLFQ 781_ QGPRD 786_ HPDIV 791_ DSFMQ 796_ LLAQA 801_ LKRKP 806_ DLFLC 811_ ERLDV 816_ KAVFQ 821_ CAVLA 826_ LKFPE 831_ APTVK 836_ ASCGF 841_ FTELL 846_ PRCGE 851_ VESVG 856_ KVVQE 861_ DGRML 866_ LIAVL 871_ EAIGG 876_ QASRS 881_ LMDCF 886_ ADILF 891_ ALNKH 896_ CFSLL 901_ SMWIK 906_ EALQP 911_ PGFPS 916_ ARLSP 921_ EQKDT 926_ FSQQI 931_ LRERV 936_ NKRRV 941_ KEMVK 946_ EFTLL 951_ CRGLH 956_GTDYT
1: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13