Phospholipase DDHD2 (EC 3.1.1.-) (DDHD domain-containing protein 2) (KIAA0725p) (SAM, WWE and DDHD domain-containing protein 1)
1_MSSVQ 6_ SQQEQ 11_ LSQSD 16_ PSPSP 21_ NSCSS 26_ FELID 31_ MDAGS 36_ LYEPV 41_ SPHWF 46_ YCKII 51_ DSKET 56_ WIPFN 61_ SEDSQ 66_ QLEEA 71_ YSSGK 76_ GCNGR 81_ VVPTD 86_ GGRYD 91_ VHLGE 96_ RMRYA 101_ VYWDE 106_ LASEV 111_ RRCTW 116_ FYKGD 121_ KDNKY 126_ VPYSE 131_ SFSQV 136_ LEETY 141_ MLAVT 146_ LDEWK 151_ KKLES 156_ PNREI 161_ IILHN 166_ PKLMV 171_ HYQPV 176_ AGSDD 181_ WGSTP 186_ TEQGR 191_ PRTVK 196_ RGVEN 201_ ISVDI 206_ HCGEP 211_ LQIDH 216_ LVFVV 221_ HGIGP 226_ ACDLR 231_ FRSIV 236_ QCVND 241_ FRSVS 246_ LNLLQ 251_ THFKK 256_ AQENQ 261_ QIGRV 266_ EFLPV 271_ NWHSP 276_ LHSTG 281_ VDVDL 286_ QRITL 291_ PSINR 296_ LRHFT 301_ NDTIL 306_ DVFFY 311_ NSPTY 316_ CQTIV 321_ DTVAS 326_ EMNRI 331_ YTLFL 336_ QRNPD 341_ FKGGV 346_ SIAGH 351_ SLGSL 356_ ILFDI 361_ LTNQK 366_ DSLGD 371_ IDSEK 376_ DSLNI 381_ VMDQG 386_ DTPTL 391_ EEDLK 396_ KLQLS 401_ EFFDI 406_ FEKEK 411_ VDKEA 416_ LALCT 421_ DRDLQ 426_ EIGIP 431_ LGPRK 436_ KILNY 441_ FSTRK 446_ NSMGI 451_ KRPAP 456_ QPASG 461_ ANIPK 466_ ESEFC 471_ SSSNT 476_ RNGDY 481_ LDVGI 486_ GQVSV 491_ KYPRL 496_ IYKPE 501_ IFFAF 506_ GSPIG 511_ MFLTV 516_ RGLKR 521_ IDPNY 526_ RFPTC 531_ KGFFN 536_ IYHPF 541_ DPVAY 546_ RIEPM 551_ VVPGV 556_ EFEPM 561_ LIPHH 566_ KGRKR 571_ MHLEL 576_ REGLT 581_ RMSMD 586_ LKNNL 591_ LGSLR 596_ MAWKS 601_ FTRAP 606_ YPALQ 611_ ASETP 616_ EETEA 621_ EPEST 626_ SEKPS 631_ DVNTE 636_ ETSVA 641_ VKEEV 646_ LPINV 651_ GMLNG 656_ GQRID 661_ YVLQE 666_ KPIES 671_ FNEYL 676_ FALQS 681_ HLCYW 686_ ESEDT 691_ VLLVL 696_ KEIYQ 701_ TQGIF 706_LDQPL
1: Diacylglycerol (DAG) and triacylglycerol (TAG) lipase required for proper lipid homeostasis in the central nervous system (PubMed:29278326, PubMed:37832604). It cooperates with PNPLA2/ATGL in neuronal TAG catabolism and hydrolyzes sn-1,3 DAG downstream of PNPLA2/ATGL (By similarity). In vitro, it also acts as a phospholipase that hydrolyzes preferentially phosphatidic acids, including 1,2-dioleoyl-sn-phosphatidic acid, phosphatidylcholine and phosphatidylethanolamine. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P), phosphatidylinositol 5-phosphate (PI(5)P) and possibly phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2). May be involved in the maintenance of the endoplasmic reticulum and/or Golgi structures. May regulate the transport between Golgi apparatus and plasma membrane