[F-actin]-monooxygenase MICAL2 (EC 1.14.13.225) (MICAL C-terminal-like protein) (Mical-cL) (Molecule interacting with CasL protein 2) (MICAL-2)
1_MGENE 6_ DEKQA 11_ QAGQV 16_ FENFV 21_ QASTC 26_ KGTLQ 31_ AFNIL 36_ TRHLD 41_ LDPLD 46_ HRNFY 51_ SKLKS 56_ KVTTW 61_ KAKAL 66_ WYKLD 71_ KRGSH 76_ KEYKR 81_ GKSCT 86_ NTKCL 91_ IVGGG 96_ PCGLR 101_ TAIEL 106_ AYLGA 111_ KVVVV 116_ EKRDS 121_ FSRNN 126_ VLHLW 131_ PFTIH 136_ DLRGL 141_ GAKKF 146_ YGKFC 151_ AGSID 156_ HISIR 161_ QLQLI 166_ LFKVA 171_ LMLGV 176_ EIHVN 181_ VEFVK 186_ VLEPP 191_ EDQEN 196_ QKIGW 201_ RAEFL 206_ PTDHS 211_ LSEFE 216_ FDVII 221_ GADGR 226_ RNTLE 231_ GFRRK 236_ EFRGK 241_ LAIAI 246_ TANFI 251_ NRNST 256_ AEAKV 261_ EEISG 266_ VAFIF 271_ NQKFF 276_ QDLKE 281_ ETGID 286_ LENIV 291_ YYKDC 296_ THYFV 301_ MTAKK 306_ QSLLD 311_ KGVII 316_ NDYID 321_ TEMLL 326_ CAENV 331_ NQDNL 336_ LSYAR 341_ EAADF 346_ ATNYQ 351_ LPSLD 356_ FAMNH 361_ YGQPD 366_ VAMFD 371_ FTCMY 376_ ASENA 381_ ALVRE 386_ RQAHQ 391_ LLVAL 396_ VGDSL 401_ LEPFW 406_ PMGTG 411_ CARGF 416_ LAAFD 421_ TAWMV 426_ KSWNQ 431_ GTPPL 436_ ELLAE 441_ RESLY 446_ RLLPQ 451_ TTPEN 456_ INKNF 461_ EQYTL 466_ DPGTR 471_ YPNLN 476_ SHCVR 481_ PHQVK 486_ HLYIT 491_ KELEH 496_ YPLER 501_ LGSVR 506_ RSVNL 511_ SRKES 516_ DIRPS 521_ KLLTW 526_ CQQQT 531_ EGYQH 536_ VNVTD 541_ LTTSW 546_ RSGLA 551_ LCAII 556_ HRFRP 561_ ELINF 566_ DSLNE 571_ DDAVE 576_ NNQLA 581_ FDVAE 586_ REFGI 591_ PPVTT 596_ GKEMA 601_ SAQEP 606_ DKLSM 611_ VMYLS 616_ KFYEL 621_ FRGTP 626_ LRPVD 631_ SWRKN 636_ YGENA 641_ DLSLA 646_ KSSIS 651_ NNYLN 656_ LTFPR 661_ KRTPR 666_ VDGQT 671_ GENDM 676_ NKRRR 681_ KGFTN 686_ LDEPS 691_ NFSSR 696_ SLGSN 701_ QECGS 706_ SKEGG 711_ NQNKV 716_ KSMAN 721_ QLLAK 726_ FEEST 731_ RNPSL 736_ MKQER 741_ RVSGI 746_ GKPVL 751_ CSSSG 756_ PPVHS 761_ CCPKP 766_ EEATP 771_ SPSPP 776_ LKRQF 781_ PSVVV 786_ TGHVL 791_ RELKQ 796_ VSAGS 801_ ECLSR 806_ PWRAR 811_ AKSDL 816_ QLGGT 821_ ENFAT 826_ LPSTR 831_ PRAQA 836_ LSGVL 841_ WRLQQ 846_ VEEKI 851_ LQKRA 856_ QNLAN 861_ REFHT 866_ KNIKE 871_ KAAHL 876_ ASMFG 881_ HGDFP 886_ QNKLL 891_ SKGLS 896_ HTHPP 901_ SPPSR 906_ LPSPD 911_ PAASS 916_ SPSTV 921_ DSASP 926_ ARKEK 931_ KSPSG 936_ FHFHP 941_ SHLRT 946_ VHPQL 951_ TVGKV 956_ SSGIG 961_ AAAEV 966_ LVNLY 971_ MNDHR 976_ PKAQA 981_ TSPDL 986_ ESMRK 991_ SFPLN 996_ LGGSD 1001_ TCYFC 1006_ KKRVY 1011_ VMERL 1016_ SAEGH 1021_ FFHRE 1026_ CFRCS 1031_ ICATT 1036_ LRLAA 1041_ YTFDC 1046_ DEGKF 1051_ YCKPH 1056_ FIHCK 1061_ TNSKQ 1066_ RKRRA 1071_ ELKQQ 1076_ REEEA 1081_ TWQEQ 1086_ EAPRR 1091_ DTPTE 1096_ SSCAV 1101_ AAIGT 1106_ LEGSP 1111_ PDEPT 1116_ SPKRP 1121_ KSISE 1126_ PQHSD 1131_ AEGDA 1136_ ASPLP 1141_ SEWTS 1146_ VRISP 1151_ GEEAA 1156_ GQDVL 1161_ AVRVL 1166_ VTSED 1171_ SSSDT 1176_ ESDYG 1181_ GSEGS 1186_ HTEPC 1191_ EEKPW 1196_ RPGSP 1201_ HLPHT 1206_ SLGEA 1211_ LSRAV 1216_ SPQCP 1221_ EEPRA 1226_ VHAAL 1231_ QRANS 1236_ FQSPT 1241_ PSKYQ 1246_ NWRRE 1251_ FWWSL 1256_ TPVNK 1261_ RTMSP 1266_ PKDPS 1271_ PSLPL 1276_ PSSSS 1281_ HSSSP 1286_ PSSSS 1291_ TSVSG 1296_ NAPDG 1301_ SSPPQ 1306_ MTASE 1311_ PLSQV 1316_ SRGHP 1321_ SPPTP 1326_ NFRRR 1331_ AVAQG 1336_ APREI 1341_ PLYLP 1346_ HHPKP 1351_ EWAEY 1356_ CLVSP 1361_ GEDGL 1366_ SDPAE 1371_ MTSDE 1376_ CQPAE 1381_ APLGD 1386_ IGSNH 1391_ RDPHP 1396_ IWGKD 1401_ RSWTG 1406_ QELSP 1411_ LAGED 1416_ REKGS 1421_ TGARK 1426_ EEEGG 1431_ PVLVK 1436_ EKLGL 1441_ KKLVL 1446_ TQEQK 1451_ TMLLD 1456_ WNDSI 1461_ PESVH 1466_ LKAGE 1471_ RISQK 1476_ SAENG 1481_ RGGRV 1486_ LKPVR 1491_ PLLLP 1496_ RAAGE 1501_ PLPTQ 1506_ RGAQE 1511_ KMGTP 1516_ AEQAQ 1521_ GERNV 1526_ PPPKS 1531_ PLRLI 1536_ ANAIR 1541_ RSLEP 1546_ LLSNS 1551_ EGGKK 1556_ AWAKQ 1561_ ESKTL 1566_ PAQAC 1571_ TRSFS 1576_ LRKTN 1581_ SNKDG 1586_ DQHSP 1591_ GRNQS 1596_ SAFSP 1601_ PDPAL 1606_ RTHSL 1611_ PNRPS 1616_ KVFPA 1621_ LRSPP 1626_ CSKIE 1631_ DVPTL 1636_ LEKVS 1641_ LQENF 1646_ PDASK 1651_ PPKKR 1656_ ISLFS 1661_ SLRLK 1666_ DKSFE 1671_ SFLQE 1676_ SRQRK 1681_ DIRDL 1686_ FGSPK 1691_ RKVLP 1696_ EDSAQ 1701_ ALEKL 1706_ LQPFK 1711_ STSLR 1716_ QAAPP 1721_ PPPPP 1726_ PPPPP 1731_ PPTAG 1736_ GADSK 1741_ NFPLR 1746_ AQVTE 1751_ ASSSA 1756_ SSTSS 1761_ SSADE 1766_ EFDPQ 1771_ LSLQL 1776_ KEKKT 1781_ LRRRK 1786_ KLEKA 1791_ MKQLV 1796_ KQEEL 1801_ KRLYK 1806_ AQAIQ 1811_ RQLEE 1816_ VEERQ 1821_ RASEI 1826_ QGVRL 1831_ EKALR 1836_ GEADS 1841_ GTQDE 1846_ AQLLQ 1851_ EWFKL 1856_ VLEKN 1861_ KLMRY 1866_ ESELL 1871_ IMAQE 1876_ LELED 1881_ HQSRL 1886_ EQKLR 1891_ EKMLK 1896_ EESQK 1901_ DEKDL 1906_ NEEQE 1911_ VFTEL 1916_ MQVIE 1921_ QRDKL 1926_ VDSLE 1931_ EQRIR 1936_ EKAED 1941_ QHFES 1946_ FVFSR 1951_GCQLS
1: Methionine monooxygenase that promotes depolymerization of F-actin by mediating oxidation of residues 'Met-44' and 'Met-47' on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization (PubMed:24440334, PubMed:29343822). Regulates the disassembly of branched actin networks also by oxidizing ARP3B-containing ARP2/3 complexes leading to ARP3B dissociation from the network (PubMed:34106209). Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA (PubMed:24440334)