F-BAR and double SH3 domains protein 2 (Carom) (Protein nervous wreck 1) (NWK1) (SH3 multiple domains protein 3)
1_MQPPP 6_ RKVKV 11_ TQELK 16_ NIQVE 21_ QMTKL 26_ QAKHQ 31_ AECDL 36_ LEDMR 41_ TFSQK 46_ KAAIE 51_ REYAQ 56_ GMQKL 61_ ASQYL 66_ KRDWP 71_ GVKAD 76_ DRNDY 81_ RSMYP 86_ VWKSF 91_ LEGTM 96_ QVAQS 101_ RMNIC 106_ ENYKN 111_ FISEP 116_ ARTVR 121_ SLKEQ 126_ QLKRC 131_ VDQLT 136_ KIQTE 141_ LQETV 146_ KDLAK 151_ GKKKY 156_ FETEQ 161_ MAHAV 166_ REKAD 171_ IEAKS 176_ KLSLF 181_ QSRIS 186_ LQKAS 191_ VKLKA 196_ RRSEC 201_ NSKAT 206_ HARND 211_ YLLTL 216_ AAANA 221_ HQDRY 226_ YQTDL 231_ VNIMK 236_ ALDGN 241_ VYDHL 246_ KDYLI 251_ AFSRT 256_ ELETC 261_ QAVQN 266_ TFQFL 271_ LENSS 276_ KVVRD 281_ YNLQL 286_ FLQEN 291_ AVFHK 296_ PQPFQ 301_ FQPCD 306_ SDTSR 311_ QLESE 316_ TGTTE 321_ EHSLN 326_ KEARK 331_ WATRV 336_ AREHK 341_ NIVHQ 346_ QRVLN 351_ DLECH 356_ GAAVS 361_ EQSRA 366_ ELEQK 371_ IDEAR 376_ ENIRK 381_ AEIIK 386_ LKAEA 391_ RLDLL 396_ KQIGV 401_ SVDTW 406_ LKSAM 411_ NQVME 416_ ELENE 421_ RWARP 426_ PAVTS 431_ NGTLH 436_ SLNAD 441_ TEREE 446_ GEEFE 451_ DNMDV 456_ FDDSS 461_ SSPSG 466_ TLRNY 471_ PLTCK 476_ VVYSY 481_ KASQP 486_ DELTI 491_ EEHEV 496_ LEVIE 501_ DGDME 506_ DWVKA 511_ RNKVG 516_ QVGYV 521_ PEKYL 526_ QFPTS 531_ NSLLS 536_ MLQSL 541_ AALDS 546_ RSHTS 551_ SNSTE 556_ AELVS 561_ GSLNG 566_ DASVC 571_ FVKAL 576_ YDYEG 581_ QTDDE 586_ LSFPE 591_ GAIIR 596_ ILNKE 601_ NQDDD 606_ GFWEG 611_ EFNGR 616_ IGVFP 621_ SVLVE 626_ ELSAS 631_ ENGDT 636_ PWMRE 641_ IQISP 646_ SPKPH 651_ ASLPP 656_ LPLYD 661_ QPPSS 666_ PYPSP 671_ DKRSS 676_ LYFPR 681_ SPSAN 686_ EKSLH 691_ AESPG 696_ FSQAS 701_ RHTPE 706_ TSYGK 711_ LRPVR 716_ AAPPP 721_ PTQNH 726_ RRPAE 731_KIEDV
1: Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor (PubMed:29887380). Promotes endocytosis of EGFR in cancer cells, and thereby contributes to the down-regulation of EGFR signaling (PubMed:30249660). Recruited to clathrin-coated pits during a mid-to-late stage of assembly, where it is required for normal progress from U-shaped intermediate stage pits to terminal, omega-shaped pits (PubMed:29887380). Binds to membranes enriched in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate (PubMed:29887380). When bound to membranes, promotes actin polymerization via its interaction with WAS and/or WASL which leads to the activation of the Arp2/3 complex. Does not promote actin polymerisation in the absence of membranes (PubMed:29887380)