Transmembrane and coiled-coil domains protein 1
1_MEPSG 6_ SEQLF 11_ EDPDP 16_ GGKSQ 21_ DAEAR 26_ KQTES 31_ EQKLS 36_ KMTHN 41_ ALENI 46_ NVIGQ 51_ GLKHL 56_ FQHQR 61_ RRSSV 66_ SPHDV 71_ QQIQA 76_ DPEPE 81_ MDLES 86_ QNACA 91_ EIDGV 96_ PTHPT 101_ ALNRV 106_ LQQIR 111_ VPPKM 116_ KRGTS 121_ LHSRR 126_ GKPEA 131_ PKGSP 136_ QINRK 141_ SGQEM 146_ TAVMQ 151_ SGRPR 156_ SSSTT 161_ DAPTS 166_ SAMME 171_ IACAA 176_ AAAAA 181_ ACLPG 186_ EEGTA 191_ ERIER 196_ LEVSS 201_ LAQTS 206_ SAVAS 211_ STDGS 216_ IHTDS 221_ VDGTP 226_ DPQRT 231_ KAAIA 236_ HLQQK 241_ ILKLT 246_ EQIKI 251_ AQTAR 256_ DDNVA 261_ EYLKL 266_ ANSAD 271_ KQQAA 276_ RIKQV 281_ FEKKN 286_ QKSAQ 291_ TILQL 296_ QKKLE 301_ HYHRK 306_ LREVE 311_ QNGIP 316_ RQPKD 321_ VFRDM 326_ HQGLK 331_ DVGAK 336_ VTGFS 341_ EGVVD 346_ SVKGG 351_ FSSFS 356_ QATHS 361_ AAGAV 366_ VSKPR 371_ EIASL 376_ IRNKF 381_ GSADN 386_ IPNLK 391_ DSLEE 396_ GQVDD 401_ AGKAL 406_ GVISN 411_ FQSSP 416_ KYGSE 421_ EDCSS 426_ ATSGS 431_ VGANS 436_ TTGGI 441_ AVGAS 446_ SSKTN 451_ TLDMQ 456_ SSGFD 461_ ALLHE 466_ IQEIR 471_ ETQAR 476_ LEESF 481_ ETLKE 486_ HYQRD 491_ YSLIM 496_ QTLQE 501_ ERYRC 506_ ERLEE 511_ QLNDL 516_ TELHQ 521_ NEILN 526_ LKQEL 531_ ASMEE 536_ KIAYQ 541_ SYERA 546_ RDIQE 551_ ALEAC 556_ QTRIS 561_ KMELQ 566_ QQQQQ 571_ VVQLE 576_ GLENA 581_ TARNL 586_ LGKLI 591_ NILLA 596_ VMAVL 601_ LVFVS 606_ TVANC 611_ VVPLM 616_ KTRNR 621_ TFSTL 626_ FLVVF 631_ IAFLW 636_ KHWDA 641_ LFSYV 646_ERFFS
1: Endoplasmic reticulum membrane protein that promotes endoplasmic reticulum-associated endosome fission (PubMed:30220460). Localizes to contact sites between the endoplasmic reticulum and endosomes and acts by promoting recruitment of the endoplasmic reticulum to endosome tubules for fission (PubMed:30220460). Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane (PubMed:30220460)