SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein)
1_MEDAG 6_ AAGPG 11_ PEPEP 16_ EPEPE 21_ PEPAP 26_ EPEPE 31_ PKPGA 36_ GTSEA 41_ FSRLW 46_ TDVMG 51_ ILDGS 56_ LGNID 61_ DLAQQ 66_ YADYY 71_ NTCFS 76_ DVCER 81_ MEELR 86_ KRRVS 91_ QDLEV 96_ EKPDA 101_ SPTSL 106_ QLRSQ 111_ IEESL 116_ GFCSA 121_ VSTPE 126_ VERKN 131_ PLHKS 136_ NSEDS 141_ SVGKG 146_ DWKKK 151_ NKYFW 156_ QNFRK 161_ NQKGI 166_ MRQTS 171_ KGEDV 176_ GYVAS 181_ EITMS 186_ DEERI 191_ QLMMM 196_ VKEKM 201_ ITIEE 206_ ALARL 211_ KEYEA 216_ QHRQS 221_ AALDP 226_ ADWPD 231_ GSYPT 236_ FDGSS 241_ NCNSR 246_ EQSDD 251_ ETEES 256_ VKFKR 261_ LHKLV 266_ NSTRR 271_ VRKKL 276_ IRVEE 281_ MKKPS 286_ TEGGE 291_ EHVFE 296_ NSPVL 301_ DERSA 306_ LYSGV 311_ HKKPL 316_ FFDGS 321_ PEKPP 326_ EDDSD 331_ SLTTS 336_ PSSSS 341_ LDTWG 346_ AGRKL 351_ VKTFS 356_ KGESR 361_ GLIKP 366_ PKKMG 371_ TFFSY 376_ PEEEK 381_ AQKVS 386_ RSLTE 391_ GEMKK 396_ GLGSL 401_ SHGRT 406_ CSFGG 411_ FDLTN 416_ RSLHV 421_ GSNNS 426_ DPMGK 431_ EGDFV 436_ YKEVI 441_ KSPTA 446_ SRISL 451_ GKKVK 456_ SVKET 461_ MRKRM 466_ SKKYS 471_ SSVSE 476_ QDSGL 481_ DGMPG 486_ SPPPS 491_ QPDPE 496_ HLDKP 501_ KLKAG 506_ GSVES 511_ LRSSL 516_ SGQSS 521_ MSGQT 526_ VSTTD 531_ SSTSN 536_ RESVK 541_ SEDGD 546_ DEEPP 551_ YRGPF 556_ CGRAR 561_ VHTDF 566_ TPSPY 571_ DTDSL 576_ KLKKG 581_ DIIDI 586_ ISKPP 591_ MGTWM 596_ GLLNN 601_ KVGTF 606_ KFIYV 611_ DVLSE 616_ DEEKP 621_ KRPTR 626_ RRRKG 631_ RPPQP 636_ KSVED 641_ LLDRI 646_ NLKEH 651_ MPTFL 656_ FNGYE 661_ DLDTF 666_ KLLEE 671_ EDLDE 676_ LNIRD 681_ PEHRA 686_ VLLTA 691_ VELLQ 696_ EYDSN 701_ SDQSG 706_ SQEKL 711_ LVDSQ 716_ GLSGC 721_ SPRDS 726_ GCYES 731_ SENLE 736_ NGKTR 741_ KASLL 746_ SAKSS 751_ TEPSL 756_ KSFSR 761_ NQLGN 766_ YPTLP 771_ LMKSG 776_ DALKQ 781_ GQEEG 786_ RLGGG 791_ LAPDT 796_ SKSCD 801_ PPGVT 806_ GLNKN 811_ RRSLP 816_ VSICR 821_ SCETL 826_ EGPQT 831_ VDTWP 836_ RSHSL 841_ DDLQV 846_ EPGAE 851_ QDVPT 856_ EVTEP 861_ PPQIV 866_ PEVPQ 871_ KTTAS 876_ STKAQ 881_ PLEQD 886_ SAVDN 891_ ALLLT 896_ QSKRF 901_ SEPQK 906_ LTTKK 911_ LEGSI 916_ AASGR 921_ GLSPP 926_ QCLPR 931_ NYDAQ 936_ PPGAK 941_ HGLAR 946_ TPLEG 951_ HRKGH 956_ EFEGT 961_ HHPLG 966_ TKEGV 971_ DAEQR 976_ MQPKI 981_ PSQPP 986_ PVPAK 991_ KSRER 996_ LANGL 1001_ HPVPM 1006_ GPSGA 1011_ LPSPD 1016_ APCLP 1021_ VKRGS 1026_ PASPT 1031_ SPSDC 1036_ PPALA 1041_ PRPLS 1046_ GQAPG 1051_ SPPST 1056_ RPPPW 1061_ LSELP 1066_ ENTSL 1071_ QEHGV 1076_ KLGPA 1081_ LTRKV 1086_ SCARG 1091_ VDLET 1096_ LTENK 1101_ LHAEG 1106_ IDLTE 1111_ EPYSD 1116_ KHGRC 1121_ GIPEA 1126_ LVQRY 1131_ AEDLD 1136_ QPERD 1141_ VAANM 1146_ DQIRV 1151_ KQLRK 1156_ QHRMA 1161_ IPSGG 1166_ LTEIC 1171_ RKPVS 1176_ PGCIS 1181_ SVSDW 1186_ LISIG 1191_ LPMYA 1196_ GTLST 1201_ AGFST 1206_ LSQVP 1211_ SLSHT 1216_ CLQEA 1221_ GITEE 1226_ RHIRK 1231_ LLSAA 1236_ RLFKL 1241_PPGPE
1: Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175). Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175). Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659). Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175). Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244)