CSC1-like protein 1 (Transmembrane protein 63A)
1_MMDSP 6_ FLELW 11_ QSKAV 16_ SIREQ 21_ LGLGD 26_ RPNDS 31_ YCYNS 36_ AKNST 41_ VLQGV 46_ TFGGI 51_ PTVLL 56_ IDVSC 61_ FLFLI 66_ LVFSI 71_ IRRRF 76_ WDYGR 81_ IALVS 86_ EADSE 91_ SRFQR 96_ LSSTS 101_ SSGQQ 106_ DFENE 111_ LGCCP 116_ WLTAI 121_ FRLHD 126_ DQILE 131_ WCGED 136_ AIHYL 141_ SFQRH 146_ IIFLL 151_ VVVSF 156_ LSLCV 161_ ILPVN 166_ LSGDL 171_ LDKDP 176_ YSFGR 181_ TTIAN 186_ LQTDN 191_ DLLWL 196_ HTIFA 201_ VIYLF 206_ LTVGF 211_ MRHHT 216_ QSIKY 221_ KEENL 226_ VRRTL 231_ FITGL 236_ PRDAR 241_ KETVE 246_ SHFRD 251_ AYPTC 256_ EVVDV 261_ QLCYN 266_ VAKLI 271_ YLCKE 276_ KKKTE 281_ KSLTY 286_ YTNLQ 291_ VKTGQ 296_ RTLIN 301_ PKPCG 306_ QFCCC 311_ EVLGC 316_ EWEDA 321_ ISYYT 326_ RMKDR 331_ LLERI 336_ TEEER 341_ HVQDQ 346_ PLGMA 351_ FVTFQ 356_ EKSMA 361_ TYILK 366_ DFNAC 371_ KCQSL 376_ QCKGE 381_ PQPSS 386_ HSREL 391_ YTSKW 396_ TVTFA 401_ ADPED 406_ ICWKN 411_ LSIQG 416_ LRWWL 421_ QWLGI 426_ NFTLF 431_ LGLFF 436_ LTTPS 441_ IILST 446_ MDKFN 451_ VTKPI 456_ HALNN 461_ PIISQ 466_ FFPTL 471_ LLWSF 476_ SALLP 481_ SIVYY 486_ STLLE 491_ SHWTK 496_ SGENQ 501_ IMMTK 506_ VYIFL 511_ IFMVL 516_ ILPSL 521_ GLTSL 526_ DFFFR 531_ WLFDK 536_ TSSEA 541_ SIRLE 546_ CVFLP 551_ DQGAF 556_ FVNYV 561_ IASAF 566_ IGNGM 571_ ELLRL 576_ PGLIL 581_ YTFRM 586_ IMAKT 591_ AADRR 596_ NVKQN 601_ QAFQY 606_ EFGAM 611_ YAWML 616_ CVFTV 621_ IVAYS 626_ ITCPI 631_ IAPFG 636_ LIYIL 641_ LKHMV 646_ DRHNL 651_ YFVYL 656_ PAKLE 661_ KGIHF 666_ AAVNQ 671_ ALAAP 676_ ILCLF 681_ WLYFF 686_ SFLRL 691_ GMKAP 696_ ATLFT 701_ FLVLL 706_ LTILV 711_ CLAHT 716_ CFGCF 721_ KHLSP 726_ LNYKT 731_ EEPAS 736_ DKGSE 741_ AEAHM 746_ PPPFT 751_ PYVPR 756_ ILNGL 761_ ASERT 766_ ALSPQ 771_ QQQQQ 776_ TYGAI 781_ HNISG 786_ TIPGQ 791_ CLAQS 796_ ATGSV 801_AAAPQ
1: Mechanosensitive cation channel with low conductance and high activation threshold (PubMed:30382938, PubMed:31587869, PubMed:37543036). In contrast to TMEM63B, does not show phospholipid scramblase activity (PubMed:39716028). Acts as a regulator of lysosomal morphology by mediating lysosomal mechanosensitivity (By similarity). Important for the baby's first breath and respiration throughout life (PubMed:38127458). Upon lung inflation conducts cation currents in alveolar type 1 and 2 cells triggering lamellar body exocytosis and surfactant secretion into airspace (PubMed:38127458). Also acts as an osmosensitive cation channel preferentially activated by hypotonic stress (By similarity)