FERM, ARHGEF and pleckstrin domain-containing protein 2 (FERM domain-including RhoGEF) (FIR) (FERM, RhoGEF and pleckstrin domain-containing protein 2) (Pleckstrin homology domain-containing family C member 3) (PH domain-containing family C member 3)
1_MGEIE 6_ GTYRV 11_ LQTAG 16_ MRLGA 21_ QTPVG 26_ VSTLE 31_ PGQTL 36_ LPRMQ 41_ EKHLH 46_ LRVKL 51_ LDNTM 56_ EIFDI 61_ EPKCD 66_ GQVLL 71_ TQVWK 76_ RLNLV 81_ ECDYF 86_ GMEFQ 91_ NTQSY 96_ WIWLE 101_ PMKPI 106_ IRQIR 111_ RPKNV 116_ VLRLA 121_ VKFFP 126_ PDPGQ 131_ LQEEY 136_ TRYLF 141_ ALQLK 146_ RDLLE 151_ ERLTC 156_ ADTTA 161_ ALLTS 166_ HLLQS 171_ EIGDY 176_ DETLD 181_ REHLK 186_ VNEYL 191_ PGQQH 196_ CLEKI 201_ LEFHQ 206_ KHVGQ 211_ TPAES 216_ DFQVL 221_ EIARK 226_ LEMYG 231_ IRFHM 236_ ASDRE 241_ GTKIQ 246_ LAVSH 251_ MGVLV 256_ FQGTT 261_ KINTF 266_ NWSKV 271_ RKLSF 276_ KRKRF 281_ LIKLH 286_ PEVHG 291_ PYQDT 296_ LEFLL 301_ GSRDE 306_ CKNFW 311_ KICVE 316_ YHTFF 321_ RLLDQ 326_ PKPKA 331_ KAVFF 336_ SRGSS 341_ FRYSG 346_ RTQKQ 351_ LVDYF 356_ KDSGM 361_ KRIPY 366_ ERRHS 371_ KTHTS 376_ VRALT 381_ ADLPK 386_ QSISF 391_ PEGLR 396_ TPASP 401_ SSANA 406_ FYSLS 411_ PSTLV 416_ PSGLP 421_ EFKDS 426_ SSSLT 431_ DPQVS 436_ YVKSP 441_ AAERR 446_ SGAVA 451_ GGPDT 456_ PSAQP 461_ LGPPA 466_ LQPGP 471_ GLSTK 476_ SPQPS 481_ PSSRK 486_ SPLSL 491_ SPAFQ 496_ VPLGP 501_ AEQGS 506_ SPLLS 511_ PVLSD 516_ AGGAG 521_ MDCEE 526_ PRHKR 531_ VPADE 536_ AYFIV 541_ KEILA 546_ TERTY 551_ LKDLE 556_ VITVW 561_ FRSAV 566_ VKEDA 571_ MPATL 576_ MTLLF 581_ SNIDP 586_ IYEFH 591_ RGFLR 596_ EVEQR 601_ LALWE 606_ GPSKA 611_ HTKGS 616_ HQRIG 621_ DILLR 626_ NMRQL 631_ KEFTS 636_ YFQRH 641_ DEVLT 646_ ELEKA 651_ TKRCK 656_ KLEAV 661_ YKEFE 666_ LQKVC 671_ YLPLN 676_ TFLLK 681_ PIQRL 686_ LHYRL 691_ LLRRL 696_ CGHYS 701_ PGHHD 706_ YADCH 711_ DALKA 716_ ITEVT 721_ TTLQH 726_ ILIRL 731_ ENLQK 736_ LTELQ 741_ RDLVG 746_ IENLI 751_ APGRE 756_ FIREG 761_ CLHKL 766_ TKKGL 771_ QQRMF 776_ FLFSD 781_ MLLYT 786_ SKGVA 791_ GTSHF 796_ RIRGL 801_ LPLQG 806_ MLVEE 811_ SDNEW 816_ SVPHC 821_ FTIYA 826_ AQKTI 831_ VVAAS 836_ TRLEK 841_ EKWML 846_ DLNSA 851_ IQAAK 856_ SGGDT 861_ APALP 866_ GRTVC 871_ TRPPR 876_ SPNEV 881_ SLEQE 886_ SEDDA 891_ RGVRS 896_ SLEGH 901_ GQHRA 906_ NTTMH 911_ VCWYR 916_ NTSVS 921_ RADHS 926_ AAVEN 931_ QLSGY 936_ LLRKF 941_ KNSHG 946_ WQKLW 951_ VVFTN 956_ FCLFF 961_ YKTHQ 966_ DDYPL 971_ ASLPL 976_ LGYSV 981_ SIPRE 986_ ADGIH 991_ KDYVF 996_ KLQFK 1001_ SHVYF 1006_ FRAES 1011_ KYTFE 1016_ RWMEV 1021_ IQGAS 1026_ SSAGR 1031_ APSIV 1036_ QDGPQ 1041_ PSSGL 1046_EGMVR
1: Functions as a guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity)