Kelch-like protein 18
1_MVEDG 6_ AEELE 11_ DLVHF 16_ SVSEL 21_ PSRGY 26_ GVMEE 31_ IRRQG 36_ KLCDV 41_ TLKIG 46_ DHKFS 51_ AHRIV 56_ LAASI 61_ PYFHA 66_ MFTND 71_ MMECK 76_ QDEIV 81_ MQGMD 86_ PSALE 91_ ALINF 96_ AYNGN 101_ LAIDQ 106_ QNVQS 111_ LLMGA 116_ SFLQL 121_ QSIKD 126_ ACCTF 131_ LRERL 136_ HPKNC 141_ LGVRQ 146_ FAETM 151_ MCAVL 156_ YDAAN 161_ SFIHQ 166_ HFVEV 171_ SMSEE 176_ FLALP 181_ LEDVL 186_ ELVSR 191_ DELNV 196_ KSEEQ 201_ VFEAA 206_ LAWVR 211_ YDREQ 216_ RGPYL 221_ PELLS 226_ NIRLP 231_ LCRPQ 236_ FLSDR 241_ VQQDD 246_ LVRCC 251_ HKCRD 256_ LVDEA 261_ KDYHL 266_ MPERR 271_ PHLPA 276_ FRTRP 281_ RCCTS 286_ IAGLI 291_ YAVGG 296_ LNSAG 301_ DSLNV 306_ VEVFD 311_ PIANC 316_ WERCR 321_ PMTTA 326_ RSRVG 331_ VAVVN 336_ GLLYA 341_ IGGYD 346_ GQLRL 351_ STVEA 356_ YNPET 361_ DTWTR 366_ VGSMN 371_ SKRSA 376_ MGTVV 381_ LDGQI 386_ YVCGG 391_ YDGNS 396_ SLSSV 401_ ETYSP 406_ ETDKW 411_ TVVTS 416_ MSSNR 421_ SAAGV 426_ TVFEG 431_ RIYVS 436_ GGHDG 441_ LQIFS 446_ SVEHY 451_ NHHTA 456_ TWHPA 461_ AGMLN 466_ KRCRH 471_ GAASL 476_ GSKMF 481_ VCGGY 486_ DGSGF 491_ LSIAE 496_ MYSSV 501_ ADQWC 506_ LIVPM 511_ HTRRS 516_ RVSLV 521_ ASCGR 526_ LYAVG 531_ GYDGQ 536_ SNLSS 541_ VEMYD 546_ PETDC 551_ WTFMA 556_ PMACH 561_ EGGVG 566_VGCIP
1: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis (PubMed:23213400). The BCR(KLHL18) E3 ubiquitin ligase complex mediates the ubiquitination of AURKA leading to its activation at the centrosome which is required for initiating mitotic entry (PubMed:23213400). Regulates light-and dark-dependent alpha-transducin localization changes in rod photoreceptors through UNC119 ubiquitination and degradation (By similarity). Preferentially ubiquitinates the unphosphorylated form of UNC119 over the phosphorylated form (By similarity). In the presence of UNC119, under dark-adapted conditions alpha-transducin mislocalizes from the outer segment to the inner part of rod photoreceptors which leads to decreased photoreceptor damage caused by light (By similarity)