Thymocyte selection-associated high mobility group box protein TOX (Thymus high mobility group box protein TOX)
1_MDVRF 6_ YPPPA 11_ QPAAA 16_ PDAPC 21_ LGPSP 26_ CLDPY 31_ YCNKF 36_ DGENM 41_ YMSMT 46_ EPSQD 51_ YVPAS 56_ QSYPG 61_ PSLES 66_ EDFNI 71_ PPITP 76_ PSLPD 81_ HSLVH 86_ LNEVE 91_ SGYHS 96_ LCHPM 101_ NHNGL 106_ LPFHP 111_ QNMDL 116_ PEITV 121_ SNMLG 126_ QDGTL 131_ LSNSI 136_ SVMPD 141_ IRNPE 146_ GTQYS 151_ SHPQM 156_ AAMRP 161_ RGQPA 166_ DIRQQ 171_ PGMMP 176_ HGQLT 181_ TINQS 186_ QLSAQ 191_ LGLNM 196_ GGSNV 201_ PHNSP 206_ SPPGS 211_ KSATP 216_ SPSSS 221_ VHEDE 226_ GDDTS 231_ KINGG 236_ EKRPA 241_ SDMGK 246_ KPKTP 251_ KKKKK 256_ KDPNE 261_ PQKPV 266_ SAYAL 271_ FFRDT 276_ QAAIK 281_ GQNPN 286_ ATFGE 291_ VSKIV 296_ ASMWD 301_ GLGEE 306_ QKQVY 311_ KKKTE 316_ AAKKE 321_ YLKQL 326_ AAYRA 331_ SLVSK 336_ SYSEP 341_ VDVKT 346_ SQPPQ 351_ LINSK 356_ PSVFH 361_ GPSQA 366_ HSALY 371_ LSSHY 376_ HQQPG 381_ MNPHL 386_ TAMHP 391_ SLPRN 396_ IAPKP 401_ NNQMP 406_ VTVSI 411_ ANMAV 416_ SPPPP 421_ LQISP 426_ PLHQH 431_ LNMQQ 436_ HQPLT 441_ MQQPL 446_ GNQLP 451_ MQVQS 456_ ALHSP 461_ TMQQG 466_ FTLQP 471_ DYQTI 476_ INPTS 481_ TAAQV 486_ VTQAM 491_ EYVRS 496_ GCRNP 501_ PPQPV 506_ DWNND 511_ YCSSG 516_ GMQRD 521_KALYL
1: Transcriptional regulator with a major role in neural stem cell commitment and corticogenesis as well as in lymphoid cell development and lymphoid tissue organogenesis (By similarity). Binds to GC-rich DNA sequences in the proximity of transcription start sites and may alter chromatin structure, modifying access of transcription factors to DNA. During cortical development, controls the neural stem cell pool by inhibiting the switch from proliferative to differentiating progenitors. Beyond progenitor cells, promotes neurite outgrowth in newborn neurons migrating to reach the cortical plate. May activate or repress critical genes for neural stem cell fate such as SOX2, EOMES and ROBO2 (By similarity). Plays an essential role in the development of lymphoid tissue-inducer (LTi) cells, a subset necessary for the formation of secondary lymphoid organs: peripheral lymph nodes and Peyer's patches. Acts as a developmental checkpoint and regulates thymocyte positive selection toward T cell lineage commitment. Required for the development of various T cell subsets, including CD4-positive helper T cells, CD8-positive cytotoxic T cells, regulatory T cells and CD1D-dependent natural killer T (NKT) cells. Required for the differentiation of common lymphoid progenitors (CMP) to innate lymphoid cells (ILC) (By similarity). May regulate the NOTCH-mediated gene program, promoting differentiation of the ILC lineage. Required at the progenitor phase of NK cell development in the bone marrow to specify NK cell lineage commitment (By similarity) (PubMed:21126536). Upon chronic antigen stimulation, diverts T cell development by promoting the generation of exhaustive T cells, while suppressing effector and memory T cell programming. May regulate the expression of genes encoding inhibitory receptors such as PDCD1 and induce the exhaustion program, to prevent the overstimulation of T cells and activation-induced cell death (By similarity)