SUN domain-containing protein 1 (Protein unc-84 homolog A) (Sad1/unc-84 protein-like 1)
1_MDFSR 6_ LHMYS 11_ PPQCV 16_ PENTG 21_ YTYAL 26_ SSSYS 31_ SDALD 36_ FETEH 41_ KLDPV 46_ FDSPR 51_ MSRRS 56_ LRLAT 61_ TACTL 66_ GDGEA 71_ VGADS 76_ GTSSA 81_ VSLKN 86_ RAART 91_ TKQRR 96_ STNKS 101_ AFSIN 106_ HVSRQ 111_ VTSSG 116_ VSHGG 121_ TVSLQ 126_ DAVTR 131_ RPPVL 136_ DESWI 141_ REQTT 146_ VDHFW 151_ GLDDD 156_ GDLKG 161_ GNKAA 166_ IQGNG 171_ DVGAA 176_ AATAH 181_ NGFSC 186_ SNCSM 191_ LSERK 196_ DVLTA 201_ HPAAP 206_ GPVSR 211_ VYSRD 216_ RNQKC 221_ YFLLQ 226_ ILRRI 231_ GAVGQ 236_ AVSRT 241_ AWSAL 246_ WLAVV 251_ APGKA 256_ ASGVF 261_ WWLGI 266_ GWYQF 271_ VTLIS 276_ WLNVF 281_ LLTRC 286_ LRNIC 291_ KFLVL 296_ LIPLF 301_ LLLAG 306_ LSLRG 311_ QGNFF 316_ SFLPV 321_ LNWAS 326_ MHRTQ 331_ RVDDP 336_ QDVFK 341_ PTTSR 346_ LKQPL 351_ QGDSE 356_ AFPWH 361_ WMSGV 366_ EQQVA 371_ SLSGQ 376_ CHHHG 381_ ENLRE 386_ LTTLL 391_ QKLQA 396_ RVDQM 401_ EGGAA 406_ GPSAS 411_ VRDAV 416_ GQPPR 421_ ETDFM 426_ AFHQE 431_ HEVRM 436_ SHLED 441_ ILGKL 446_ REKSE 451_ AIQKE 456_ LEQTK 461_ QKTIS 466_ AVGEQ 471_ LLPTV 476_ EHLQL 481_ ELDQL 486_ KSELS 491_ SWRHV 496_ KTGCE 501_ TVDAV 506_ QERVD 511_ VQVRE 516_ MVKLL 521_ FSEDQ 526_ QGGSL 531_ EQLLQ 536_ RFSSQ 541_ FVSKG 546_ DLQTM 551_ LRDLQ 556_ LQILR 561_ NVTHH 566_ VSVTK 571_ QLPTS 576_ EAVVS 581_ AVSEA 586_ GASGI 591_ TEAQA 596_ RAIVN 601_ SALKL 606_ YSQDK 611_ TGMVD 616_ FALES 621_ GGGSI 626_ LSTRC 631_ SETYE 636_ TKTAL 641_ MSLFG 646_ IPLWY 651_ FSQSP 656_ RVVIQ 661_ PDIYP 666_ GNCWA 671_ FKGSQ 676_ GYLVV 681_ RLSMM 686_ IHPAA 691_ FTLEH 696_ IPKTL 701_ SPTGN 706_ ISSAP 711_ KDFAV 716_ YGLEN 721_ EYQEE 726_ GQLLG 731_ QFTYD 736_ QDGES 741_ LQMFQ 746_ ALKRP 751_ DDTAF 756_ QIVEL 761_ RIFSN 766_ WGHPE 771_ YTCLY 776_RFRVH
1: As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton (PubMed:18039933, PubMed:18396275). The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (By similarity). Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration (By similarity). Involved in telomere attachment to nuclear envelope in the prophase of meiosis implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly (By similarity). Required for gametogenesis and involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis (By similarity). Helps to define the distribution of nuclear pore complexes (NPCs) (By similarity). Required for efficient localization of SYNE4 in the nuclear envelope (By similarity). May be involved in nuclear remodeling during sperm head formation in spermatogenesis (By similarity). May play a role in DNA repair by suppressing non-homologous end joining repair to facilitate the repair of DNA cross-links (PubMed:24375709)