Erlin-2 (Endoplasmic reticulum lipid raft-associated protein 2) (Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2) (SPFH domain-containing protein 2)
1_MAQLG 6_ AVVAV 11_ ASSFF 16_ CASLF 21_ SAVHK 26_ IEEGH 31_ IGVYY 36_ RGGAL 41_ LTSTS 46_ GPGFH 51_ LMLPF 56_ ITSYK 61_ SVQTT 66_ LQTDE 71_ VKNVP 76_ CGTSG 81_ GVMIY 86_ FDRIE 91_ VVNFL 96_ VPNAV 101_ YDIVK 106_ NYTAD 111_ YDKAL 116_ IFNKI 121_ HHELN 126_ QFCSV 131_ HTLQE 136_ VYIEL 141_ FDQID 146_ ENLKL 151_ ALQQD 156_ LTSMA 161_ PGLVI 166_ QAVRV 171_ TKPNI 176_ PEAIR 181_ RNYEL 186_ MESEK 191_ TKLLI 196_ AAQKQ 201_ KVVEK 206_ EAETE 211_ RKKAL 216_ IEAEK 221_ VAQVA 226_ EITYG 231_ QKVME 236_ KETEK 241_ KISEI 246_ EDAAF 251_ LAREK 256_ AKADA 261_ ECYTA 266_ MKIAE 271_ ANKLK 276_ LTPEY 281_ LQLMK 286_ YKAIA 291_ SNSKI 296_ YFGKD 301_ IPNMF 306_ MDSAG 311_ SVSKQ 316_ FEGLA 321_ DKLSF 326_ GLEDE 331_PLETA
1: Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1 (PubMed:17502376, PubMed:19240031). Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex (PubMed:21343306). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex (PubMed:24217618)