Dickkopf-related protein 1 (Dickkopf-1) (Dkk-1) (hDkk-1) (SK)
1_MMALG 6_ AAGAT 11_ RVFVA 16_ MVAAA 21_ LGGHP 26_ LLGVS 31_ ATLNS 36_ VLNSN 41_ AIKNL 46_ PPPLG 51_ GAAGH 56_ PGSAV 61_ SAAPG 66_ ILYPG 71_ GNKYQ 76_ TIDNY 81_ QPYPC 86_ AEDEE 91_ CGTDE 96_ YCASP 101_ TRGGD 106_ AGVQI 111_ CLACR 116_ KRRKR 121_ CMRHA 126_ MCCPG 131_ NYCKN 136_ GICVS 141_ SDQNH 146_ FRGEI 151_ EETIT 156_ ESFGN 161_ DHSTL 166_ DGYSR 171_ RTTLS 176_ SKMYH 181_ TKGQE 186_ GSVCL 191_ RSSDC 196_ ASGLC 201_ CARHF 206_ WSKIC 211_ KPVLK 216_ EGQVC 221_ TKHRR 226_ KGSHG 231_ LEIFQ 236_ RCYCG 241_ EGLSC 246_ RIQKD 251_ HHQAS 256_ NSSRL 261_HTCQR
1: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6 (PubMed:22000856). DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (PubMed:17143291). Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity (By similarity)