ABC-type organic anion transporter ABCA8 (EC 7.6.2.-) (ATP-binding cassette sub-family A member 8)
1_MRKRK 6_ ISVCQ 11_ QTWAL 16_ LCKNF 21_ LKKWR 26_ MKRES 31_ LMEWL 36_ NSLLL 41_ LLCLY 46_ IYPHS 51_ HQVND 56_ FSSLL 61_ TMDLG 66_ RVDTF 71_ NESRF 76_ SVVYT 81_ PVTNT 86_ TQQIM 91_ NKVAS 96_ TPFLA 101_ GKEVL 106_ GLPDE 111_ ESIKE 116_ FTANY 121_ PEEIV 126_ RVTFT 131_ NTYSY 136_ HLKFL 141_ LGHGM 146_ PAKKE 151_ HKDHT 156_ AHCYE 161_ TNEDV 166_ YCEVS 171_ VFWKE 176_ GFVAL 181_ QAAIN 186_ AAIIE 191_ ITTNH 196_ SVMEE 201_ LMSVT 206_ GKNMK 211_ MHSFI 216_ GQSGV 221_ ITDLY 226_ LFSCI 231_ ISFSS 236_ FIYYA 241_ SVNVT 246_ RERKR 251_ MKALM 256_ TMMGL 261_ RDSAF 266_ WLSWG 271_ LLYAG 276_ FIFIM 281_ ALFLA 286_ LVIRS 291_ TQFII 296_ LSGFM 301_ VVFSL 306_ FLLYG 311_ LSLVA 316_ LAFLM 321_ SILVK 326_ KSFLT 331_ GLVVF 336_ LLTVF 341_ WGCLG 346_ FTSLY 351_ RHLPA 356_ SLEWI 361_ LSLLS 366_ PFAFM 371_ LGMAQ 376_ LLHLD 381_ YDLNS 386_ NAFPH 391_ PSDGS 396_ NLIVA 401_ TNFML 406_ AFDTC 411_ LYLAL 416_ AIYFE 421_ KILPN 426_ EYGHR 431_ RPPLF 436_ FLKSS 441_ FWSQT 446_ QKTDH 451_ VALED 456_ EMDAD 461_ PSFHD 466_ SFEQA 471_ PPEFQ 476_ GKEAI 481_ RIRNV 486_ TKEYK 491_ GKPDK 496_ IEALK 501_ DLVFD 506_ IYEGQ 511_ ITAIL 516_ GHSGA 521_ GKSTL 526_ LNILS 531_ GLSVP 536_ TKGSV 541_ TIYNN 546_ KLSEM 551_ ADLEN 556_ LSKLT 561_ GVCPQ 566_ SNVQF 571_ DFLTV 576_ RENLR 581_ LFAKI 586_ KGILP 591_ QEVDK 596_ EIQRV 601_ LLELE 606_ MKNIQ 611_ DVLAQ 616_ NLSGG 621_ QKRKL 626_ TFGIA 631_ ILGDP 636_ QIFLL 641_ DEPTA 646_ GLDPF 651_ SRHQV 656_ WNLLK 661_ ERKTD 666_ RVILF 671_ STQFM 676_ DEADI 681_ LADRK 686_ VFLSQ 691_ GKLKC 696_ AGSSL 701_ FLKKK 706_ WGIGY 711_ HLSLQ 716_ LNEIC 721_ VEENI 726_ TSLVK 731_ QHIPD 736_ AKLSA 741_ KSEGK 746_ LIYTL 751_ PLERT 756_ NKFPE 761_ LYKDL 766_ DSYPD 771_ LGIEN 776_ YGVSM 781_ TTLNE 786_ VFLKL 791_ EGKST 796_ INESD 801_ IAILG 806_ EVQAE 811_ KADDT 816_ ERLVE 821_ MEQVL 826_ SSLNK 831_ MRKTI 836_ GGVAL 841_ WRQQI 846_ CAIAR 851_ VRLLK 856_ LKHER 861_ KALLA 866_ LLLIL 871_ MAGFC 876_ PLLVE 881_ YTMVK 886_ IYQNS 891_ YTWEL 896_ SPHLY 901_ FLAPG 906_ QQPHD 911_ PLTQL 916_ LIINK 921_ TGASI 926_ DDFIQ 931_ SVEHQ 936_ NIALE 941_ VDAFG 946_ TRNGT 951_ DDPSY 956_ NGAIT 961_ VCCNE 966_ KNYSF 971_ SLACN 976_ AKRLN 981_ CFPVL 986_ MDIVS 991_ NGLLG 996_ MVKPS 1001_ VHIRT 1006_ ERSTF 1011_ LENGQ 1016_ DNPIG 1021_ FLAYI 1026_ MFWLV 1031_ LTSSC 1036_ PPYIA 1041_ MSSID 1046_ DYKNR 1051_ ARSQL 1056_ RISGL 1061_ SPSAY 1066_ WFGQA 1071_ LVDVS 1076_ LYFLV 1081_ FVFIY 1086_ LMSYI 1091_ SNFED 1096_ MLLTI 1101_ IHIIQ 1106_ IPCAV 1111_ GYSFS 1116_ LIFMT 1121_ YVISF 1126_ IFRKG 1131_ RKNSG 1136_ IWSFC 1141_ FYVVT 1146_ VFSVA 1151_ GFAFS 1156_ IFESD 1161_ IPFIF 1166_ TFLIP 1171_ PATMI 1176_ GCLFL 1181_ SSHLL 1186_ FSSLF 1191_ SEERM 1196_ DVQPF 1201_ LVFLI 1206_ PFLHF 1211_ IIFLF 1216_ TLRCL 1221_ EWKFG 1226_ KKSMR 1231_ KDPFF 1236_ RISPR 1241_ SSDVC 1246_ QNPEE 1251_ PEGED 1256_ EDVQM 1261_ ERVRT 1266_ ANALN 1271_ STNFD 1276_ EKPVI 1281_ IASCL 1286_ RKEYA 1291_ GKRKG 1296_ CFSKR 1301_ KNKIA 1306_ TRNVS 1311_ FCVRK 1316_ GEVLG 1321_ LLGHN 1326_ GAGKS 1331_ TSIKV 1336_ ITGDT 1341_ KPTAG 1346_ QVLLK 1351_ GSGGG 1356_ DALEF 1361_ LGYCP 1366_ QENAL 1371_ WPNLT 1376_ VRQHL 1381_ EVYAA 1386_ VKGLR 1391_ KGDAE 1396_ VAITR 1401_ LVDAL 1406_ KLQDQ 1411_ LKSPV 1416_ KTLSE 1421_ GIKRK 1426_ LCFVL 1431_ SILGN 1436_ PSVVL 1441_ LDEPS 1446_ TGMDP 1451_ EGQQQ 1456_ MWQAI 1461_ RATFR 1466_ NTERG 1471_ ALLTT 1476_ HYMAE 1481_ AEAVC 1486_ DRVAI 1491_ MVSGR 1496_ LRCIG 1501_ SIQHL 1506_ KSKFG 1511_ KDYLL 1516_ EMKVK 1521_ NLAQV 1526_ EPLHA 1531_ EILRL 1536_ FPQAA 1541_ RQERY 1546_ SSLMV 1551_ YKLPV 1556_ EDVQP 1561_ LAQAF 1566_ FKLEK 1571_ VKQSF 1576_ DLEEY 1581_ SLSQS 1586_ TLEQV 1591_ FLELS 1596_ KEQEL 1601_ GDFEE 1606_ DFDPS 1611_ VKWKL 1616_LPQEE
1: Catalyzes ATP-dependent import of organic anions such as taurocholate and estrone sulfate (PubMed:12379217). In vitro, also imports ochratoxin A (PubMed:12379217). Also mediates cholesterol efflux independent of apolipoprotein, and plays a role in sphingomyelin production in oligodendrocytes (PubMed:23560799)
2: Catalyzes ATP-dependent efflux of cholesterol and taurocholate (PubMed:29300488). Interaction with ABCA1 potentiates cholesterol efflux to lipid-free APOA1, which regulates high-density lipoprotein cholesterol levels (PubMed:28882873)