Nuclear factor of activated T-cells 5 (NF-AT5) (T-cell transcription factor NFAT5) (Tonicity-responsive enhancer-binding protein) (TonE-binding protein) (TonEBP)
1_MPSDF 6_ ISLLS 11_ ADLDL 16_ ESPKS 21_ LYSRE 26_ SVYDL 31_ LPKEL 36_ QLPPS 41_ RETSV 46_ ASMSQ 51_ TSGGE 56_ AGSPP 61_ PAVVA 66_ ADASS 71_ APSSS 76_ SMGGA 81_ CSSFT 86_ TSSSP 91_ TIYST 96_ SVTDS 101_ KAMQV 106_ ESCSS 111_ AVGVS 116_ NRGVS 121_ EKQLT 126_ SNTVQ 131_ QHPST 136_ PKRHT 141_ VLYIS 146_ PPPED 151_ LLDNS 156_ RMSCQ 161_ DEGCG 166_ LESEQ 171_ SCSMW 176_ MEDSP 181_ SNFSN 186_ MSTSS 191_ YNDNT 196_ EVPRK 201_ SRKRN 206_ PKQRP 211_ GVKRR 216_ DCEES 221_ NMDIF 226_ DADSA 231_ KAPHY 236_ VLSQL 241_ TTDNK 246_ GNSKA 251_ GNGTL 256_ ENQKG 261_ TGVKK 266_ SPMLC 271_ GQYPV 276_ KSEGK 281_ ELKIV 286_ VQPET 291_ QHRAR 296_ YLTEG 301_ SRGSV 306_ KDRTQ 311_ QGFPT 316_ VKLEG 321_ HNEPV 326_ VLQVF 331_ VGNDS 336_ GRVKP 341_ HGFYQ 346_ ACRVT 351_ GRNTT 356_ PCKEV 361_ DIEGT 366_ TVIEV 371_ GLDPS 376_ NNMTL 381_ AVDCV 386_ GILKL 391_ RNADV 396_ EARIG 401_ IAGSK 406_ KKSTR 411_ ARLVF 416_ RVNIM 421_ RKDGS 426_ TLTLQ 431_ TPSSP 436_ ILCTQ 441_ PAGVP 446_ EILKK 451_ SLHSC 456_ SVKGE 461_ EEVFL 466_ IGKNF 471_ LKGTK 476_ VIFQE 481_ NVSDE 486_ NSWKS 491_ EAEID 496_ MELFH 501_ QNHLI 506_ VKVPP 511_ YHDQH 516_ ITLPV 521_ SVGIY 526_ VVTNA 531_ GRSHD 536_ VQPFT 541_ YTPDP 546_ AAAGA 551_ LNVNV 556_ KKEIS 561_ SPARP 566_ CSFEE 571_ AMKAM 576_ KTTGC 581_ NLDKV 586_ NIIPN 591_ ALMTP 596_ LIPSS 601_ MIKSE 606_ DVTPM 611_ EVTAE 616_ KRSST 621_ IFKTT 626_ KSVGS 631_ TQQTL 636_ ENISN 641_ IAGNG 646_ SFSSP 651_ SSSHL 656_ PSENE 661_ KQQQI 666_ QPKAY 671_ NPETL 676_ TTIQT 681_ QDISQ 686_ PGTFP 691_ AVSAS 696_ SQLPN 701_ SDALL 706_ QQATQ 711_ FQTRE 716_ TQSRE 721_ ILQSD 726_ GTVVN 731_ LSQLT 736_ EASQQ 741_ QQQSP 746_ LQEQA 751_ QTLQQ 756_ QISSN 761_ IFPSP 766_ NSVSQ 771_ LQNTI 776_ QQLQA 781_ GSFTG 786_ STASG 791_ SSGSV 796_ DLVQQ 801_ VLEAQ 806_ QQLSS 811_ VLFSA 816_ PDGNE 821_ NVQEQ 826_ LSADI 831_ FQQVS 836_ QIQSG 841_ VSPGM 846_ FSSTE 851_ PTVHT 856_ RPDNL 861_ LPGRA 866_ ESVHP 871_ QSENT 876_ LSNQQ 881_ QQQQQ 886_ QQQVM 891_ ESSAA 896_ MVMEM 901_ QQSIC 906_ QAAAQ 911_ IQSEL 916_ FPSTA 921_ SANGN 926_ LQQSP 931_ VYQQT 936_ SHMMS 941_ ALSTN 946_ EDMQM 951_ QCELF 956_ SSPPA 961_ VSGNE 966_ TSTTT 971_ TQQVA 976_ TPGTT 981_ MFQTS 986_ SSGDG 991_ EETGT 996_ QAKQI 1001_ QNSVF 1006_ QTMVQ 1011_ MQHSG 1016_ DNQPQ 1021_ VNLFS 1026_ STKSM 1031_ MSVQN 1036_ SGTQQ 1041_ QGNGL 1046_ FQQGN 1051_ EMMSL 1056_ QSGNF 1061_ LQQSS 1066_ HSQAQ 1071_ LFHPQ 1076_ NPIAD 1081_ AQNLS 1086_ QETQG 1091_ SLFHS 1096_ PNPIV 1101_ HSQTS 1106_ TTSSE 1111_ QMQPP 1116_ MFHSQ 1121_ STIAV 1126_ LQGSS 1131_ VPQDQ 1136_ QSTNI 1141_ FLSQS 1146_ PMNNL 1151_ QTNTV 1156_ AQEAF 1161_ FAAPN 1166_ SISPL 1171_ QSTSN 1176_ SEQQA 1181_ AFQQQ 1186_ APISH 1191_ IQTPM 1196_ LSQEQ 1201_ AQPPQ 1206_ QGLFQ 1211_ PQVAL 1216_ GSLPP 1221_ NPMPQ 1226_ SQQGT 1231_ MFQSQ 1236_ HSIVA 1241_ MQSNS 1246_ PSQEQ 1251_ QQQQQ 1256_ QQQQQ 1261_ QQQQQ 1266_ QSILF 1271_ SNQNT 1276_ MATMA 1281_ SPKQP 1286_ PPNMI 1291_ FNPNQ 1296_ NPMAN 1301_ QEQQN 1306_ QSIFH 1311_ QQSNM 1316_ APMNQ 1321_ EQQPM 1326_ QFQSQ 1331_ STVSS 1336_ LQNPG 1341_ PTQSE 1346_ SSQTP 1351_ LFHSS 1356_ PQIQL 1361_ VQGSP 1366_ SSQEQ 1371_ QVTLF 1376_ LSPAS 1381_ MSALQ 1386_ TSINQ 1391_ QDMQQ 1396_ SPLYS 1401_ PQNNM 1406_ PGIQG 1411_ ATSSP 1416_ QPQAT 1421_ LFHNT 1426_ AGGTM 1431_ NQLQN 1436_ SPGSS 1441_ QQTSG 1446_ MFLFG 1451_ IQNNC 1456_ SQLLT 1461_ SGPAT 1466_ LPDQL 1471_ MAISQ 1476_ PGQPQ 1481_ NEGQP 1486_ PVTTL 1491_ LSQQM 1496_ PENSP 1501_ LASSI 1506_ NTNQN 1511_ IEKID 1516_ LLVSL 1521_ QNQGN 1526_NLTGS
1: Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3' (PubMed:10377394). Mediates the transcriptional response to hypertonicity (PubMed:10051678). Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17 (PubMed:22266867). Also involved in the DNA damage response by preventing formation of R-loops; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:34049076)