Cyclin-dependent kinase 14 (EC 2.7.11.22) (Cell division protein kinase 14) (Serine/threonine-protein kinase PFTAIRE-1) (hPFTAIRE1)
1_MCDLI 6_ EPQPA 11_ EKIGK 16_ MKKLR 21_ RTLSE 26_ SFSRI 31_ ALKKD 36_ DTTFD 41_ EICVT 46_ KMSTR 51_ NCQGM 56_ DSVIK 61_ PLDTI 66_ PEDKK 71_ VRVQR 76_ TQSTF 81_ DPFEK 86_ PANQV 91_ KRVHS 96_ ENNAC 101_ INFKT 106_ SSTGK 111_ ESPKV 116_ RRHSS 121_ PSSPT 126_ SPKFG 131_ KADSY 136_ EKLEK 141_ LGEGS 146_ YATVY 151_ KGKSK 156_ VNGKL 161_ VALKV 166_ IRLQE 171_ EEGTP 176_ FTAIR 181_ EASLL 186_ KGLKH 191_ ANIVL 196_ LHDII 201_ HTKET 206_ LTLVF 211_ EYVHT 216_ DLCQY 221_ MDKHP 226_ GGLHP 231_ DNVKL 236_ FLFQL 241_ LRGLS 246_ YIHQR 251_ YILHR 256_ DLKPQ 261_ NLLIS 266_ DTGEL 271_ KLADF 276_ GLARA 281_ KSVPS 286_ HTYSN 291_ EVVTL 296_ WYRPP 301_ DVLLG 306_ STEYS 311_ TCLDM 316_ WGVGC 321_ IFVEM 326_ IQGVA 331_ AFPGM 336_ KDIQD 341_ QLERI 346_ FLVLG 351_ TPNED 356_ TWPGV 361_ HSLPH 366_ FKPER 371_ FTLYS 376_ SKNLR 381_ QAWNK 386_ LSYVN 391_ HAEDL 396_ ASKLL 401_ QCSPK 406_ NRLSA 411_ QAALS 416_ HEYFS 421_ DLPPR 426_ LWELT 431_ DMSSI 436_ FTVPN 441_ VRLQP 446_ EAGES 451_ MRAFG 456_ KNNSY 461_GKSLS
1: Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport