D-glucuronyl C5-epimerase (EC 5.1.3.17) (Heparan sulfate C5-epimerase) (Hsepi) (Heparin/heparan sulfate:glucuronic acid C5-epimerase) (Heparosan-N-sulfate-glucuronate 5-epimerase)
1_MRCLA 6_ ARVNY 11_ KTLII 16_ ICALF 21_ TLVTV 26_ LLWNK 31_ CSSDK 36_ AIQFP 41_ RRSSS 46_ GFRVD 51_ GFEKR 56_ AAASE 61_ SNNYM 66_ NHVAK 71_ QQSEE 76_ AFPQE 81_ QQKAP 86_ PVVGG 91_ FNSNV 96_ GSKVL 101_ GLKYE 106_ EIDCL 111_ INDEH 116_ TIKGR 121_ REGNE 126_ VFLPF 131_ TWVEK 136_ YFDVY 141_ GKVVQ 146_ YDGYD 151_ RFEFS 156_ HSYSK 161_ VYAQR 166_ APYHP 171_ DGVFM 176_ SFEGY 181_ NVEVR 186_ DRVKC 191_ ISGVE 196_ GVPLS 201_ TQWGP 206_ QGYFY 211_ PIQIA 216_ QYGLS 221_ HYSKN 226_ LTEKP 231_ PHIEV 236_ YETAE 241_ DRDKN 246_ KPNDW 251_ TVPKG 256_ CFMAN 261_ VADKS 266_ RFTNV 271_ KQFIA 276_ PETSE 281_ GVSLQ 286_ LGNTK 291_ DFIIS 296_ FDLKF 301_ LTNGS 306_ VSVVL 311_ ETTEK 316_ NQLFT 321_ IHYVS 326_ NAQLI 331_ AFKER 336_ DIYYG 341_ IGPRT 346_ SWSTV 351_ TRDLV 356_ TDLRK 361_ GVGLS 366_ NTKAV 371_ KPTKI 376_ MPKKV 381_ VRLIA 386_ KGKGF 391_ LDNIT 396_ ISTTA 401_ HMAAF 406_ FAASD 411_ WLVRN 416_ QDEKG 421_ GWPIM 426_ VTRKL 431_ GEGFK 436_ SLEPG 441_ WYSAM 446_ AQGQA 451_ ISTLV 456_ RAYLL 461_ TKDHI 466_ FLNSA 471_ LRATA 476_ PYKFL 481_ SEQHG 486_ VKAVF 491_ MNKHD 496_ WYEEY 501_ PTTPS 506_ SFVLN 511_ GFMYS 516_ LIGLY 521_ DLKET 526_ AGEKL 531_ GKEAR 536_ SLYER 541_ GMESL 546_ KAMLP 551_ LYDTG 556_ SGTIY 561_ DLRHF 566_ MLGIA 571_ PNLAR 576_ WDYHT 581_ THINQ 586_ LQLLS 591_ TIDES 596_ PVFKE 601_ FVKRW 606_ KSYLK 611_GSRAK
1: Converts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate (HS) and heparin chains. This is important for further modifications that determine the specificity of interactions between these glycosaminoglycans and proteins