Glutaminase kidney isoform, mitochondrial (GLS) (EC 3.5.1.2) (K-glutaminase) (L-glutamine amidohydrolase) [Cleaved into: Glutaminase kidney isoform, mitochondrial 68 kDa chain; Glutaminase kidney isoform, mitochondrial 65 kDa chain]
1_MMRLR 6_ GSGML 11_ RDLLL 16_ RSPAG 21_ VSATL 26_ RRAQP 31_ LVTLC 36_ RRPRG 41_ GGRPA 46_ AGPAA 51_ AARLH 56_ PWWGG 61_ GGWPA 66_ EPLAR 71_ GLSSS 76_ PSEIL 81_ QELGK 86_ GSTHP 91_ QPGVS 96_ PPAAP 101_ AAPGP 106_ KDGPG 111_ ETDAF 116_ GNSEG 121_ KELVA 126_ SGENK 131_ IKQGL 136_ LPSLE 141_ DLLFY 146_ TIAEG 151_ QEKIP 156_ VHKFI 161_ TALKS 166_ TGLRT 171_ SDPRL 176_ KECMD 181_ MLRLT 186_ LQTTS 191_ DGVML 196_ DKDLF 201_ KKCVQ 206_ SNIVL 211_ LTQAF 216_ RRKFV 221_ IPDFM 226_ SFTSH 231_ IDELY 236_ ESAKK 241_ QSGGK 246_ VADYI 251_ PQLAK 256_ FSPDL 261_ WGVSV 266_ CTVDG 271_ QRHST 276_ GDTKV 281_ PFCLQ 286_ SCVKP 291_ LKYAI 296_ AVNDL 301_ GTEYV 306_ HRYVG 311_ KEPSG 316_ LRFNK 321_ LFLNE 326_ DDKPH 331_ NPMVN 336_ AGAIV 341_ VTSLI 346_ KQGVN 351_ NAEKF 356_ DYVMQ 361_ FLNKM 366_ AGNEY 371_ VGFSN 376_ ATFQS 381_ ERESG 386_ DRNFA 391_ IGYYL 396_ KEKKC 401_ FPEGT 406_ DMVGI 411_ LDFYF 416_ QLCSI 421_ EVTCE 426_ SASVM 431_ AATLA 436_ NGGFC 441_ PITGE 446_ RVLSP 451_ EAVRN 456_ TLSLM 461_ HSCGM 466_ YDFSG 471_ QFAFH 476_ VGLPA 481_ KSGVA 486_ GGILL 491_ VVPNV 496_ MGMMC 501_ WSPPL 506_ DKMGN 511_ SVKGI 516_ HFCHD 521_ LVSLC 526_ NFHNY 531_ DNLRH 536_ FAKKL 541_ DPRRE 546_ GGDQR 551_ VKSVI 556_ NLLFA 561_ AYTGD 566_ VSALR 571_ RFALS 576_ AMDME 581_ QRDYD 586_ SRTAL 591_ HVAAA 596_ EGHVE 601_ VVKFL 606_ LEACK 611_ VNPFP 616_ KDRWN 621_ NTPMD 626_ EALHF 631_ GHHDV 636_ FKILQ 641_ EYQVQ 646_ YTPQG 651_ DSDNG 656_ KENQT 661_VHKNL
1: Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate, the main excitatory neurotransmitter in the brain (PubMed:30239721, PubMed:30575854, PubMed:30970188)
2: Lacks catalytic activity